Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: This study evaluates levels of matrix metalloproteinase (MMP)-8, MMP-9, and tissue inhibitor of MP-1 (TIMP-1) in biofluids of women with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different statuses of periodontal health. Methods: Seventy-one women with GDM and gingivitis (Gg), 30 women with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh), and 37 systemically healthy women with gingivitis (Hg) were evaluated. MMP-8, MMP-9, and TIMP-1 levels were determined in gingival crevicular fluid (GCF), saliva, and serum by immunofluorometric and enzyme-linked immunosorbent assays. Fullmouth clinical periodontal parameters were recorded. Results: GCF and serum MMP-8 concentrations, serum MMP-9 concentrations, and serum MMP-8/MMP-1 and MMP9/MMP-1 molar ratios were significantly higher in Gg compared with Hg group (P < 0.05). Serum MMP-8 levels and salivary TIMP-1 levels were higher in Gh compared with Hg group (P < 0.05) whereas salivary MMP-8/TIMP-1 molar ratio was lower in Gh compared with Hg group (P < 0.05). Elevated concentrations of GCF MMP-8 and MMP-9 were found in Gg compared with Gh group (P < 0.05). Significant correlations were found between local levels of biomarkers and clinical periodontal parameters in only GDM group. Conclusion: GDM may modulate both local and circulating levels of MMP-8 especially when associated with gingivitis.
Açıklama
Anahtar Kelimeler
Diabetes, gestational, gingivitis, gingival crevicular fluid, matrix metalloproteinases, saliva, serum
Kaynak
Journal of Periodontology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
88
Sayı
3
