Olası Herpetik Ön Üveitlerde Göz İçi Basıncı Yüksekliğinin Sıklığı ve Prognozu
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Tarih
2016
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info:eu-repo/semantics/openAccess
Özet
Amaç: Herpetik ön üveitlerde göz içi basınç yüksekliğinin (GİB) sıklığını saptamak ve klinik özelliklerinin prognoza olan etkisini araştırmak.Gereç ve Yöntem: Herpetik ön üveit tanısı alan hastalara ait tıbbi kayıtlar retrospektif olarak incelendi. Hastalar GİB normal seyreden (Grup 1), oküler hipertansiyon (OHT) saptanan (Grup 2) ve glokom gelişenler (Grup 3) olmak üzere 3 gruba ayrıldı. Klinik sonuç ile klinik bulgular arasındaki ilişki araştırıldı. Bulgular: Altmış altı hastanın (32 kadın, 34 erkek) 66 gözü çalışmaya dahil edildi. Ortalama yaş 49.2±18.9 yıl, ortalama takip süresi 20.7±23.2 ay idi. İzlem sırasında 41 gözde (%62.1) GİB yüksekliği saptandı. Bunların 14 (%34.1)'ünde glokomatöz optik sinir defekti geliştiği görüldü. Yedi gözde (%50) GİB medikal tedavi ile kontrol altına alınırken 7 göze cerrahi uygulandı. Gruplar karşılaştırıldığında ön kamara reaksiyon şiddeti, atak sayısı, rekürrens sıklığı açısından farklılık göstermezken (p=0,332, p=0,098, p=0,457; Mann Whitney U test), granülomatöz keratik presipitatların (KP) varlığı OHT saptananlarda, korneal vaskülarizasyon gelişimi ise glokom gelişenlerde anlamlı yüksek bulundu (p=0.041, p:0.003; ki-kare testi).Sonuç: Herpetik ön üveitli hastalarda GİB yüksekliği oldukça sık (%62.1) olarak görülmekte ancak bunların az bir kısmı (%17.1) cerrahi girişim gerektirmektedir. Çalışmada klinik özellikler içerisinde granülomatöz KP varlığı oküler hipertansiyon sıklığında artış ile, korneal vaskülarizasyon varlığı ise hastalığın ciddiyeti ve uzun seyrinin bir göstergesi olarak artmış glokom riski ile ilişkili bulunmuştur.
Purpose: To determine the prevalence of elevated intraocular pressure (IOP) and to investigate the effect of clinical signs on its prognosis in patients with presumed herpetic anterior uveitis.Materials and Methods: the medical records of patients diagnosed as herpetic anterior uveitis were reviewed. Patients were divided into 3 groups, as having normal IOP during the course (Group 1), ocular hypertension (OHT) (Group 2) and secondary glaucoma (Group 3). Relationship between clinical signs and outcomes were investigated.Results: Sixty-six eyes of 66 patients (32 female, 34 male) were included in the study. the mean age was 49.2±18.9 years, the mean follow-up time was 20.7±23.2 months. During follow-up elevated IOP was noted in 41 eyes (62.1%). Fourteen of them (34.1%) were evaluated as having glaucomatous defect. IOP was regulated with medical treatment in 7 eyes (50%), however other 7 eyes required surgical intervention. There was no difference in between groups, regarding anterior segment reaction severity, number of attacks and recurrence rates (p=0.332, p=0.098, p=0.457; Mann Whitney U test). Presence of granulomatous KPs was more prevalent in Group 2 and corneal vascularization was higher in Group 3, significantly (p=0.041, p:0.003; chi-square test).Conclusion: Elevated IOP is considerably common (%62.1) in patients with herpetic anterior uveitis; however only quite a few of them (17.1%) requires surgery. Presence of granulomatous KPs was related with increased prevalence of OHT. As an indicator of disease severity and chronicity, corneal vascularization was related with increased glaucoma risk.
Purpose: To determine the prevalence of elevated intraocular pressure (IOP) and to investigate the effect of clinical signs on its prognosis in patients with presumed herpetic anterior uveitis.Materials and Methods: the medical records of patients diagnosed as herpetic anterior uveitis were reviewed. Patients were divided into 3 groups, as having normal IOP during the course (Group 1), ocular hypertension (OHT) (Group 2) and secondary glaucoma (Group 3). Relationship between clinical signs and outcomes were investigated.Results: Sixty-six eyes of 66 patients (32 female, 34 male) were included in the study. the mean age was 49.2±18.9 years, the mean follow-up time was 20.7±23.2 months. During follow-up elevated IOP was noted in 41 eyes (62.1%). Fourteen of them (34.1%) were evaluated as having glaucomatous defect. IOP was regulated with medical treatment in 7 eyes (50%), however other 7 eyes required surgical intervention. There was no difference in between groups, regarding anterior segment reaction severity, number of attacks and recurrence rates (p=0.332, p=0.098, p=0.457; Mann Whitney U test). Presence of granulomatous KPs was more prevalent in Group 2 and corneal vascularization was higher in Group 3, significantly (p=0.041, p:0.003; chi-square test).Conclusion: Elevated IOP is considerably common (%62.1) in patients with herpetic anterior uveitis; however only quite a few of them (17.1%) requires surgery. Presence of granulomatous KPs was related with increased prevalence of OHT. As an indicator of disease severity and chronicity, corneal vascularization was related with increased glaucoma risk.
Açıklama
Anahtar Kelimeler
Göz Hastalıkları
Kaynak
Glokom Katarakt
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
4
