Antibacterial activity of porphyrin derivatives against multidrug-resistant bacteria

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dc.contributor.authorTasli, Huseyin
dc.contributor.authorAkbiyik, Ayse
dc.contributor.authorAlptuzun, Vildan
dc.contributor.authorParlar, Sulunay
dc.date.accessioned2020-12-01T12:09:23Z
dc.date.available2020-12-01T12:09:23Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionTasli, Huseyin/0000-0003-0216-1740en_US
dc.description.abstractIn this study, it was aimed to investigate the antibacterial activities of the cationic porphyrin derivatives against some multi drug resistant clinical bacterial isolates and standard strains for the development of potential antibacterial agents. in addition to the standard strains, methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa clinical isolates were studied. We synthesized eight (P1-P8) cationic porphyrin derivatives. the minimum inhibitory concentrations (MIC) of these substances were determined by micro dilution method. Ciprofloxacin was used for quality control. the study was repeated three times. All porphyrin derivatives exhibited antibacterial activity at different levels according to the studied bacteria. the strongest antibacterial activity was obtained with compounds P6, P7 and P8. These compounds were found to have MIC values of <5-156 mu g/ml. Because of the low MIC values, it has been concluded that these synthesized porphyrin derivatives may be high-potency agents against bacteria with high resistance profile.en_US
dc.identifier.endpage2373en_US
dc.identifier.issn1011-601X
dc.identifier.issue5en_US
dc.identifier.pmid31894020en_US
dc.identifier.startpage2369en_US
dc.identifier.urihttps://hdl.handle.net/11454/63429
dc.identifier.volume32en_US
dc.identifier.wosWOS:000493108500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-bacterial agentsen_US
dc.subjectporphyrinsen_US
dc.subjectbacteriaen_US
dc.subjectmultidrug resistanceen_US
dc.titleAntibacterial activity of porphyrin derivatives against multidrug-resistant bacteriaen_US
dc.typeArticleen_US

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