Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

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dc.authoridorman, mehmet/0000-0003-3544-9329
dc.authorscopusid57223883991
dc.authorscopusid7004013649
dc.authorscopusid6701401491
dc.authorscopusid24764869600
dc.authorscopusid7202725945
dc.authorscopusid57035592300
dc.authorscopusid6602749604
dc.contributor.authorSarica, Anil S.
dc.contributor.authorBor, Serhat
dc.contributor.authorOrman, Mehmet N.
dc.contributor.authorBarajas-Martinez, Hector
dc.contributor.authorJuang, Jyh-Ming Jimmy
dc.contributor.authorAntzelevitch, Charles
dc.contributor.authorHasdemir, Can
dc.date.accessioned2023-01-12T19:54:22Z
dc.date.available2023-01-12T19:54:22Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractIrritable bowel syndrome (IBS) is one of the most widely recognized functional bowel disorders (FBDs) with a genetic component. SCN5A gene and SCN1B loci have been identified in population-based IBS cohorts and proposed to have a mechanistic role in the pathophysiology of IBS. These same genes have been associated with Brugada syndrome (BrS). The present study examines the hypothesis that these two inherited syndromes are linked. Prevalence of FBDs over a 12 months period were compared between probands with BrS/ drug-induced type 1 Brugada pattern (DI-Type 1 BrP) (n = 148) and a control group (n = 124) matched for age, female sex, presence of arrhythmia and co-morbid conditions. SCN5A/SCN1B genes were screened in 88 patients. Prevalence of IBS was 25% in patients with BrS/DI-Type 1 BrP and 8.1% in the control group (p = 2.34 x 10(-4)). On stepwise logistic regression analysis, presence of current and/or history of migraine (OR of 2.75; 95% CI: 1.08 to 6.98; p = 0.033) was a predictor of underlying BrS/DI-Type 1 BrP among patients with FBDs. We identified 8 putative SCN5A/SCN1B variants in 7 (12.3%) patients with BrS/ DI-Type 1 BrP and 1 (3.2%) patient in control group. Five out of 8 (62.5%) patients with SCN5A/SCN1B variants had FBDs. In conclusion, IBS is a common co-morbidity in patients with BrS/DI-Type 1 BrP. Presence of current and/or history of migraine are a predictor of underlying BrS/DI-Type 1 BrP among patients with FBDs. Frequent co-existence of IBS and BrS/DI-Type 1 BrP necessitates cautious use of certain drugs among the therapeutic options for IBS that are known to exacerbate the Brugada phenotype. (C) 2021 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipNIH [HL47678, HL138103, HL152201]; W.W. Smith Charitable Trust; Wistar and Martha Morris Funden_US
dc.description.sponsorship\ This work was supported by grants from the NIH (HL47678, HL138103, and HL152201), W.W. Smith Charitable Trust and Wistar and Martha Morris Fund.en_US
dc.identifier.doi10.1016/j.amjcard.2021.04.010
dc.identifier.endpage56en_US
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.pmid34034907en_US
dc.identifier.scopus2-s2.0-85106361988en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2021.04.010
dc.identifier.urihttps://hdl.handle.net/11454/76392
dc.identifier.volume151en_US
dc.identifier.wosWOS:000664767900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Inc-Elsevier Science Incen_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChannelopathiesen_US
dc.subjectFamiliesen_US
dc.subjectMutationen_US
dc.subjectRisken_US
dc.titleFrequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Patternen_US
dc.typeArticleen_US

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