Host-Parasite Interactions: Regulation of Leishmania Infection in Sand Fly

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dc.authoridOmondi, Zeph Nelson/0000-0003-3695-0326
dc.authoridOzbel, Yusuf/0000-0001-8335-1997
dc.authoridOMONDI, ZEPH NELSON/0000-0003-3695-0326
dc.authoridARSERIM, SUHA KENAN/0000-0002-9174-6291
dc.authorscopusid57215302576
dc.authorscopusid55911250900
dc.authorscopusid55665073900
dc.authorscopusid6603630554
dc.authorwosidTöz, Seray/AHD-3178-2022
dc.authorwosidOmondi, Zeph Nelson/ADU-3159-2022
dc.authorwosidOMONDI, ZEPH NELSON/AFF-8497-2022
dc.authorwosidOzbel, Yusuf/Q-1609-2015
dc.contributor.authorOmondi, Zeph Nelson
dc.contributor.authorArserim, Suha Kenan
dc.contributor.authorToz, Seray
dc.contributor.authorOzbel, Yusuf
dc.date.accessioned2023-01-12T19:51:00Z
dc.date.available2023-01-12T19:51:00Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose Sand flies are the only proven vectors of leishmaniases, a tropical neglected disease endemic in at least 92 countries. Vector-parasite interactions play a significant role in vector-borne disease transmission. There are various bottlenecks to Leishmania colonization of the sand fly midgut. Such bottlenecks include the production of innate immune-related molecules, digestive proteases, parasite impermeable peritrophic membrane, and resident gut microbiota. These barriers determine the parasite load transmitted and, consequently, the disease outcome in mammalian host. Therefore, it is important to understand the molecular responses of both sand fly and Leishmania during infection. Method Here, we reviewed the published literature on sand fly-Leishmania interactions bringing together earlier and current findings to highlight new developments and research gaps in the field. Conclusion Recent research studies on sand fly-Leishmania interaction have revealed contrasting observations to past studies. However, how Leishmania parasites evade the sand fly immune response still needs further research. Sand fly response to Leishmania infection can be best understood by analyzing its tissue transcriptome. Better characterization of the role of midgut components could be a game changer in development of transmission-blocking strategies for leishmaniasis.en_US
dc.identifier.doi10.1007/s11686-022-00519-3
dc.identifier.endpage618en_US
dc.identifier.issn1230-2821
dc.identifier.issn1896-1851
dc.identifier.issue2en_US
dc.identifier.pmid35107776en_US
dc.identifier.scopus2-s2.0-85124159885en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.1007/s11686-022-00519-3
dc.identifier.urihttps://hdl.handle.net/11454/76207
dc.identifier.volume67en_US
dc.identifier.wosWOS:000749964600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofActa Parasitologicaen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHost-parasite interactionen_US
dc.subjectSand flyen_US
dc.subjectLeishmaniaen_US
dc.subjectVector competenceen_US
dc.subjectInnate immunityen_US
dc.subjectLutzomyia-Longipalpisen_US
dc.subjectPhlebotomus-Papatasien_US
dc.subjectPeritrophic Matrixen_US
dc.subjectDigestive Enzymesen_US
dc.subjectFliesen_US
dc.subjectDipteraen_US
dc.subjectDuboscqien_US
dc.subjectImmunityen_US
dc.subjectColonizationen_US
dc.subjectTransmissionen_US
dc.titleHost-Parasite Interactions: Regulation of Leishmania Infection in Sand Flyen_US
dc.typeReviewen_US

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