Dosimetric evaluation of different radiotherapy techniques in mastectomized left-sided breast cancer

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dc.authorscopusid47561912700
dc.authorscopusid55608832600
dc.authorscopusid56566730900
dc.authorscopusid57190134087
dc.authorscopusid58313466200
dc.authorscopusid55788286200
dc.authorscopusid6601978717
dc.contributor.authorOlacak, N.
dc.contributor.authorHazeral, Y.Z.
dc.contributor.authorHazeral, B.
dc.contributor.authorDuran, O.
dc.contributor.authorGüray, G.
dc.contributor.authorAlanyali, S.
dc.contributor.authorHaydaroğlu, A.
dc.date.accessioned2024-08-25T18:48:08Z
dc.date.available2024-08-25T18:48:08Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractCONTEXT: Inclusion of internal mammary lymph nodes in mastectomized left breast cancer radiotherapy may lead to high dose receiving risk of the heart, lung, and contralateral breast. AIM: The aim of this study is to compare the dosimetric differences of field-in-field (FIF), volumetric-modulated arc therapy (VMAT), seven-field intensity-modulated radiotherapy (7F-IMRT), and helical tomotherapy (HT) planning techniques for mastectomized left breast cancer. MATERIALS AND METHODS: Computed tomography images of ten patients treated with the FIF technique were used to compare four different treatment planning techniques. Planning target volume (PTV) included chest wall and regional lymph nodes. The heart, left anterior descending coronary artery (LAD), left and whole lung, thyroid, esophagus, and contralateral breast were identified as organs-at-risks (OARs). Except for HT, a single isocenter in PTV and bolus of thickness 0.3 cm on the chest wall was used. Complete and directional blocks were applied in HT, and the dosimetric parameters of PTV and OARs for four different techniques were analyzed using the Kruskal-Wallis test. RESULTS: 7F-IMRT, VMAT, and HT were superior to the FIF technique in providing homogeneous dose distribution covering the PTV (P < 0.0001). Mean doses (Dmean) of the contralateral breast and esophagus, lung, and body-PTV V5 (volume receiving 5 Gy) were reduced in FIF, whereas in the HT, Heart Dmean, LAD Dmean , Dmax, healthy tissue (body-PTV) Dmean , heart and left lung V20, and thyroid V30 were significantly reduced (P < 0.0001). CONCLUSIONS: FIF and HT techniques were found to be significantly advantageous over 7F-IMRT and VMAT for OARs. Using those three multiple-beam techniques reduced high-dose volumes of healthy tissues and organs in mastectomized left breast cancer radiotherapy but also increased low-dose volumes and contralateral lung and breast doses. Complete and directional blocks applied in HT reduce heart, lung, and contralateral breast doses.en_US
dc.identifier.doi10.4103/jcrt.jcrt_1018_21
dc.identifier.endpage182en_US
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.pmid37313899en_US
dc.identifier.scopus2-s2.0-85161928693en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_1018_21
dc.identifier.urihttps://hdl.handle.net/11454/102168
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofJournal of cancer research and therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBreast canceren_US
dc.subjectdosimetryen_US
dc.subjectfield-in-fielden_US
dc.subjecthelical tomotherapyen_US
dc.subjectseven-field intensity-modulated radiotherapyen_US
dc.subjectvolumetric-modulated arc therapyen_US
dc.subjectbreast tumoren_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectintensity modulated radiation therapyen_US
dc.subjectradiometryen_US
dc.subjectthorax wallen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectRadiometryen_US
dc.subjectRadiotherapy, Intensity-Modulateden_US
dc.subjectThoracic Wallen_US
dc.subjectUnilateral Breast Neoplasmsen_US
dc.titleDosimetric evaluation of different radiotherapy techniques in mastectomized left-sided breast canceren_US
dc.typeArticleen_US

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