The diagnostic value of 24-hour ambulatory intraesophageal pH-impedance in patients with laryngopharyngeal reflux symptoms comparable with typical symptoms

Basit Öğe Kaydı
dc.contributor.authorSakin, Yusuf S.
dc.contributor.authorVardar, Rukiye
dc.contributor.authorSezgin, Baha
dc.contributor.authorCetin, Zeynep Erdogan
dc.contributor.authorAlev, Yasemin
dc.contributor.authorYildirim, Esra
dc.contributor.authorKirazli, Tayfun
dc.contributor.authorBor, Serhat
dc.date.accessioned2019-10-27T11:06:44Z
dc.date.available2019-10-27T11:06:44Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The diagnosis of laryngopharyngeal reflux is currently based on a combination of the patient history of multichannel intraluminal impedance and ambulatory pH (MII-pH); however, none of these findings alone is specific for the diagnosis of laryngopharyngeal reflux. We aimed to compare the baseline characteristics and esophageal baseline impedance values between patients with and without laryngopharyngeal reflux symptoms. Methods: We retrospectively analyzed data from two groups of patients with laryngopharyngeal reflux according to their reflux finding score (RFS) as scored by ENTs. Control patients were nonerosive reflux disease patients without laryngopharyngeal reflux. All MII-pH parameters and baseline impedance were analyzed from six levels and the proximal and distal baseline impedance and the ratio of the proximal to distal baseline impedance levels was calculated. Results: Altogether 123 patients with laryngopharyngeal reflux and 49 control patients were included. A total of 81 of 123 patients had RFS >= 7, and 42 of 123 patients had RFS > 7. Baseline impedance analysis showed that patients with laryngopharyngeal reflux symptoms had significantly lower proximal baseline impedance values (1997 +/- 51 vs 2245 +/- 109, p < 0.05) than the control group. Additionally, patients with laryngopharyngeal reflux symptoms had a significantly lower proximal-to-distal ratio (1.28 +/- 0.05 vs 1.53 +/- 0.09, p < 0.05). In the subgroup analysis, patients with RFS < 7 were found to have a significantly lower acid exposure time than either the patients with RFS >= 7 (3.85 +/- 0.65 vs 8.2 +/- 1.52, p < 0.05) or the control group (3.85 +/- 0.65 vs 6.1 +/- 0.81, p < 0.05). Additionally, patients with RFS7 had significantly lower proximal baseline impedance levels than the control group (1970 +/- 63 vs 2245 +/- 109, p < 0.05). Conclusions: Patients with pathologic laryngopharyngeal reflux symptom scores had lower proximal baseline impedance levels and lower proximal-to-distal ratios, which may reflect the proximal mucosal noxious effect of the refluxate. These results may indicate that laryngopharyngeal reflux symptoms may be due to chronic acid exposure in the proximal segments of the esophagus, and the proximal-to-distal ratio may be used as a new metric for diagnosis.en_US
dc.identifier.doi10.1177/2050640616675040en_US
dc.identifier.endpage640en_US
dc.identifier.issn2050-6406
dc.identifier.issn2050-6414
dc.identifier.issue5en_US
dc.identifier.pmid28815026en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage632en_US
dc.identifier.urihttps://doi.org/10.1177/2050640616675040
dc.identifier.urihttps://hdl.handle.net/11454/31913
dc.identifier.volume5en_US
dc.identifier.wosWOS:000405291100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofUnited European Gastroenterology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBaseline impedanceen_US
dc.subjectgastroesophageal refluxen_US
dc.subjectlaryngopharyngeal refluxen_US
dc.subjectproximal to distal ratioen_US
dc.subjectreflux finding scoreen_US
dc.titleThe diagnostic value of 24-hour ambulatory intraesophageal pH-impedance in patients with laryngopharyngeal reflux symptoms comparable with typical symptomsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu