Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells

Basit Öğe Kaydı
dc.contributor.authorGul H.I.
dc.contributor.authorVepsalainen J.
dc.contributor.authorGul M.
dc.contributor.authorErciyas E.
dc.contributor.authorHanninen O.
dc.date.accessioned2019-10-27T00:26:02Z
dc.date.available2019-10-27T00:26:02Z
dc.date.issued2000
dc.departmentEge Üniversitesien_US
dc.description.abstractMannich bases of acetophenones have been disclosed to have antitumour and cytotoxic activities. 1-Phenyl-3-dimethylaminopropan-1-one hydrochloride, 1, and related piperidino, 2, and morpholino, 3, derivatives, and compound 4, which is a quaternary form of 1, were synthesized as mono Mannich bases derived from acetophenone. They were converted to corresponding bis Mannich bases, 5-8, to see whether it increases the bioactivity. The biological activity of the compounds was examined by cytotoxicity against mouse renal carcinoma (Renca) and transformed human T-lymphocyte (Jurkat) cell lines. Conversion of mono Mannich bases to corresponding bis Mannich bases remarkably increased the cytotoxicity in most cases. Quaternization procedure also improved the bioactivity in mono derivatives against Jurkat cells. Bis mannich bases 5-7 were found to be more active than 5-fluorouracil (6-23 fold) and melphalan (1.25-5 fold) against Renca cells. Except 2 and 8, the compounds synthesised were found to be more active than 5-fluorouracil (1.2- 33 fold) against Jurkat cells. (C) 2000 Elsevier Science B.V.en_US
dc.identifier.doi10.1016/S0031-6865(00)00022-4en_US
dc.identifier.endpage398en_US
dc.identifier.issn0031-6865
dc.identifier.issue4en_US
dc.identifier.pmid10812939en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1016/S0031-6865(00)00022-4
dc.identifier.urihttps://hdl.handle.net/11454/23340
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPharmaceutica Acta Helvetiaeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetophenoneen_US
dc.subjectCytotoxicityen_US
dc.subjectJurkat cellsen_US
dc.subjectMannich basesen_US
dc.subjectRenca cellsen_US
dc.subjectSynthesisen_US
dc.titleCytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cellsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu