Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop

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dc.contributor.authorHaznedaroglu M.Z.
dc.contributor.authorGokce G.
dc.date.accessioned2019-10-27T08:22:05Z
dc.date.available2019-10-27T08:22:05Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractStudies on Alzheimer's disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for treatment. Amaryllidaceae plants are well known for alkaloids showing cholinesterase inhibiting activity. Among them, Sternbergia species gained attention as a source of metabolites of these alkaloid contents. Studies have focused mainly on the bulbs of these plants. In this study the potential acetylcholinesterase (AChE) inhibitory activity of endemic Sternbergia candida Mathew & T. Baytop (Sc) species was evaluated in both bulbs and leaves in comparison with lycorine. We report for the first time that methanol and chloroform leaf extracts of the plant show AChE inhibitory (AChEI) activity. Among the leaf extracts methanolic extract was much more potent than chloroform extract by means of AChE inhibition. Although IC<inf>50</inf> values for methanolic extract was found to be lower than reference drug lycorine; this value of inhibition did not reach to a statistically significant level. Future studies aiming at investigation of the AChE inhibitory activity could be considered using leaves of the plant. © 2014 Akadémiai Kiadó, Budapest.en_US
dc.identifier.doi10.1556/ABiol.65.2014.4.4en_US
dc.identifier.endpage404en_US
dc.identifier.issn0236-5383
dc.identifier.issue4en_US
dc.identifier.pmid25475979en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage396en_US
dc.identifier.urihttps://doi.org/10.1556/ABiol.65.2014.4.4
dc.identifier.urihttps://hdl.handle.net/11454/26176
dc.identifier.volume65en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rt.en_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAche inhibitory activityen_US
dc.subjectBulbsen_US
dc.subjectLeavesen_US
dc.subjectLycorineen_US
dc.subjectSternbergia candidaen_US
dc.titleComparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytopen_US
dc.typeArticleen_US

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