Elevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitis

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dc.contributor.authorBostanci, N.
dc.contributor.authorOzturk, V. O.
dc.contributor.authorEmingil, G.
dc.contributor.authorBelibasakis, G. N.
dc.date.accessioned2019-10-27T21:42:01Z
dc.date.available2019-10-27T21:42:01Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThe Triggering Receptor Expressed on Myeloid cells 1 (TREM-1) is a cell-surface receptor of the immunoglobulin superfamily, involved in the propagation of the inflammatory response to bacterial challenge. Soluble (s) TREM-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. The hypothesis of this study was that oral and systemic levels of sTREM-1 are elevated in periodontitis. Therefore, the aim was to investigate, by ELISA, the sTREM-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. In saliva, sTREM-1 concentrations were higher in chronic and aggressive periodontitis than in the control group, by 3.3-fold and 5.6-fold, respectively. In serum, these differences were 1.7-fold and 2-fold, respectively. However, there were no significant differences between the two forms of periodontitis, neither in saliva nor in serum. Salivary and serum sTREM-1 levels positively correlated with full-mouth clinical periodontal parameters. In conclusion, the increased oral and systemic levels of sTREM-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response.en_US
dc.identifier.doi10.1177/0022034512470691en_US
dc.identifier.endpage165en_US
dc.identifier.issn0022-0345
dc.identifier.issn1544-0591
dc.identifier.issue2en_US
dc.identifier.pmid23242230en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1177/0022034512470691
dc.identifier.urihttps://hdl.handle.net/11454/46804
dc.identifier.volume92en_US
dc.identifier.wosWOS:000313629700011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Dental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTREM-1 proteinen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.subjectinflammationen_US
dc.subjectperiodontal diseasesen_US
dc.subjectELISAen_US
dc.titleElevated Oral and Systemic Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Periodontitisen_US
dc.typeArticleen_US

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