Titration of betaine therapy to optimize therapy in an infant with 5,10-methylenetetrahydrofolate reductase deficiency

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dc.contributor.authorUcar S.K.
dc.contributor.authorKoroğlu Ö.A.
dc.contributor.authorBerk Ö.
dc.contributor.authorYalaz M.
dc.contributor.authorKültürsay N.
dc.contributor.authorBlom H.J.
dc.contributor.authorCoker M.
dc.date.accessioned2019-10-26T22:48:46Z
dc.date.available2019-10-26T22:48:46Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractBetaine therapy was given for 2 years to a 2- year-old boy with 5,10-methylenetetrahydrofolate reductase deficiency. Used as a methyl donor to lower homocysteine levels through methylation of methionine, betaine has been reported to be effective in treating homocystinuria. Satisfactory biochemical and clinical responses were obtained with the following regimen: betaine started in the newborn period at increasing doses to reach 1 g given six times a day. It is suggested that frequent administration of a moderate dose may provide clinical and biochemical benefit. © Springer-Verlag 2009.en_US
dc.identifier.doi10.1007/s00431-009-0997-xen_US
dc.identifier.endpage243en_US
dc.identifier.issn0340-6199
dc.identifier.issue2en_US
dc.identifier.pmid19434424en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-009-0997-x
dc.identifier.urihttps://hdl.handle.net/11454/20194
dc.identifier.volume169en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5,10-methylenetetrahydrofolate reductase deficiencyen_US
dc.subjectBetaineen_US
dc.subjectDaily dose frequencyen_US
dc.titleTitration of betaine therapy to optimize therapy in an infant with 5,10-methylenetetrahydrofolate reductase deficiencyen_US
dc.typeArticleen_US

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