Risk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter study

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dc.contributor.authorYilmaz, Gul R.
dc.contributor.authorDizbay, Murat
dc.contributor.authorGuven, Tumer
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorTasbakan, Meltem
dc.contributor.authorGuzel, Ozlem Tunccan
dc.contributor.authorTekce, Yasemin T.
dc.contributor.authorOzden, Mehmet
dc.contributor.authorTurhan, Ozge
dc.contributor.authorGuner, Rahmet
dc.contributor.authorCag, Yasemin
dc.contributor.authorBozkurt, Fatma
dc.contributor.authorKaradag, Fatma Yilmaz
dc.contributor.authorKartal, Elif Doyuk
dc.contributor.authorGozel, Gokhan
dc.contributor.authorBulut, Cemal
dc.contributor.authorErdinc, Sebnem
dc.contributor.authorKeske, Siran
dc.contributor.authorAcikgoz, Ziya Cibali
dc.contributor.authorTasyaran, Mehmet A.
dc.date.accessioned2019-10-27T23:09:56Z
dc.date.available2019-10-27T23:09:56Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Knowing risk factors for colistin resistance is important since colistin is the only remaining choice for the treatment of infections caused by multi-drug resistant microorganisms. OBJECTIVE: Evaluate risk factors associated with infection by colistin-resistant microorganisms. DESIGN: Retrospective study. SETTINGS: Tertiary healthcare centers. PATIENTS AND METHODS: An e-mail including the title and purpose of the study was sent to 1500 infectious disease specialists via a scientific and social web portal named "Infeksiyon Dunyasi (Infection World)". Demographic and clinical data was requested from respondents. MAIN OUTCOME MEASURE(S): Colistin-resistance. RESULTS: Eighteen infectious disease specialists from twelve tertiary care centers responded to the invitation. Data was collected on 165 patients, 56 cases (39.9%) and 109 (66.0%) age-and sex-matched controls. The colistin-resistant microorganisms isolated from cases were 29 Acinetobacter baumannii (51.8%), 18 Pseudomonas aeruginosa (32.1%) and 9 Klebsiella spp. Colistin, carbapenem, and quinolone use in the last three months were risk factors for colistin resistance in the univariate analysis. Previous quinolone use in the last three months (P=.003; RR: 3.2; 95% CI: 1.5-6,7) and previous colistin use in the last three months (P=.001; RR: 3.6; 95% CI: 1.63-7.99) were significant risk factors in the multivariate analysis. CONCLUSION: Clinicians should limit the use of quinolones and remain aware of the possibility of resistance developing during colistin use. LIMITATIONS: The lack of a heteroresistance analysis on the isolates. No data on use of a loading dose or the use of colistin in combination.en_US
dc.identifier.doi10.5144/0256-4947.2016.216en_US
dc.identifier.endpage222en_US
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue3en_US
dc.identifier.pmid27236394en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage216en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2016.216
dc.identifier.urihttps://hdl.handle.net/11454/52782
dc.identifier.volume36en_US
dc.identifier.wosWOS:000384907900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherK Faisal Spec Hosp Res Centreen_US
dc.relation.ispartofAnnals of Saudi Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleRisk factors for infection with colistin-resistant gram-negative microorganisms: a multicenter studyen_US
dc.typeArticleen_US

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