Gingival crevicular fluid and plasma oxidative stress markers and TGM-2 levels in chronic periodontitis

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dc.contributor.authorBecerik, Sema
dc.contributor.authorOzturk, Veli Ozgen
dc.contributor.authorCelec, Peter
dc.contributor.authorKamodyova, Natalia
dc.contributor.authorAtilla, Gul
dc.contributor.authorEmingil, Gulnur
dc.date.accessioned2019-10-27T10:48:24Z
dc.date.available2019-10-27T10:48:24Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: This study was aimed to evaluate the gingival crevicular fluid (GCF) and plasma transglutaminase-2 (TGM-2), total antioxidant capacity (TAC), total oxidant status (TOS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) in patients with chronic periodontal disease. Materials and methods: Twenty patients with chronic periodontitis (CP), 20 patients with gingivitis and 20 healthy subjects were enrolled in the study. Clinical periodontal parameters including probing depth, clinical attachment level, plaque index and papillary bleeding index were recorded. GCF and plasma levels of TGM-2, TAC, TOS, TBARS and FRAP were analyzed. Results: GCF TGM-2 was significantly lower in CP group than in gingivitis patients (P = 0.006). GCF FRAP in CP and gingivitis groups was significantly lower than in healthy subjects (P < 0.001). Plasma FRAP level was lower in gingivitis group when compared to healthy subjects (P = 0.003). There was no significant difference in GCF and plasma TAC, TOS, TBARS and plasma TGM-2 levels among the study groups (P > 0.05). GCF TGM-2 level was positively correlated with GCF TAC and negatively correlated with CAL. Conclusions: Decreased FRAP in GCF and plasma indicating lower antioxidant status of CP patients might suggest the role of oxidative stress in periodontitis. GCF TGM-2 data might suggest that TGM2 is associated with stabilization of the extracellular matrix and wound healing in periodontium rather than gingival inflammation.en_US
dc.description.sponsorshipResearch Found of Ege University [10-DIS-014]en_US
dc.description.sponsorshipThis research was supported by Research Found of Ege University (Project no: 10-DIS-014).en_US
dc.identifier.doi10.1016/j.archoralbio.2017.06.032en_US
dc.identifier.endpage54en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.pmid28711023en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2017.06.032
dc.identifier.urihttps://hdl.handle.net/11454/31535
dc.identifier.volume83en_US
dc.identifier.wosWOS:000413280900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTransglutaminase-2en_US
dc.subjectOxidative stressen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectChronic periodontitisen_US
dc.titleGingival crevicular fluid and plasma oxidative stress markers and TGM-2 levels in chronic periodontitisen_US
dc.typeArticleen_US

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