Advances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assemblies

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dc.contributor.authorIlhan-Ayisigi E.
dc.contributor.authorYaldiz B.
dc.contributor.authorBor G.
dc.contributor.authorYaghmur A.
dc.contributor.authorYesil-Celiktas O.
dc.date.accessioned2021-05-03T20:56:54Z
dc.date.available2021-05-03T20:56:54Z
dc.date.issued2021
dc.description.abstractMicrofluidic platforms have become highly attractive tools for synthesis of nanoparticles, including lipid nano-self-assemblies, owing to unique features and at least three important aspects inherent to miniaturized micro-devices. Firstly, the fluids flow under controlled conditions in the microchannels, providing well-defined flow profiles and shorter diffusion lengths that play important roles in enhancing the continuous production of lipid and polymer nanoparticles with relatively narrow size distributions. Secondly, various geometries adapted to microfluidic device designs can be utilized for enhancing the colloidal stability of nanoparticles and improving their drug loading. Thirdly, microfluidic devices are usually compatible with in situ characterization methods for real-time monitoring of processes occurring inside the microchannels. This is unlike conventional nanoparticle synthesis methods, where a final solution or withdrawn aliquots are separately analysed. These features inherent to microfluidic devices provide a tool-set allowing not only precise nanoparticle size control, but also real-time analyses for process optimization. In this review, we focus on recent advances and developments in the use of microfluidic devices for synthesis of lipid nanoparticles. We present different designs based on hydrodynamic flow focusing, droplet-based methods and controlled microvortices, and discuss integration of microfluidic platforms with synchrotron small-angle X ray scattering (SAXS) for in situ structural characterization of lipid nano-self-assemblies under continuous flow conditions, along with major challenges and future directions in this research area. © 2021 Elsevier B.V.en_US
dc.description.sponsorshipDanish Agency for Science and Higher Educationen_US
dc.description.sponsorshipAY and OYC acknowledge the INP grant (Ref. no.: 8073-00022B) from the Danish Agency for Science and Higher Education for initiating and exploring new networking and collaboration opportunities between Danish and Turkish research institutions.en_US
dc.identifier.doi10.1016/j.colsurfb.2021.111633en_US
dc.identifier.issn0927-7765
dc.identifier.pmid33639513en_US
dc.identifier.scopus2-s2.0-85101365364en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2021.111633
dc.identifier.urihttps://hdl.handle.net/11454/71414
dc.identifier.volume201en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofColloids and Surfaces B: Biointerfacesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIn situ characterizationen_US
dc.subjectMicrofluidicsen_US
dc.subjectNano-self- assembliesen_US
dc.subjectSAXSen_US
dc.titleAdvances in microfluidic synthesis and coupling with synchrotron SAXS for continuous production and real-time structural characterization of nano-self-assembliesen_US
dc.typeReview Articleen_US

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