Value of serum CA-125 concentrations as predictors of pregnancy in assisted reproduction cycles

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dc.contributor.authorTavmergen, E
dc.contributor.authorSendag, F
dc.contributor.authorGoker, ENT
dc.contributor.authorLevi, R
dc.date.accessioned2019-10-27T18:20:11Z
dc.date.available2019-10-27T18:20:11Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractThe means by which endometrial receptivity influences conception rates in assisted reproductive technology (ART) is poorly understood. As the glycoprotein CA-125 is a product of human endometrium and is measurable in the peripheral circulation, it was investigated whether it might serve as an indicator of endometrial receptivity and predictor of pregnancy, In this prospective study, serum CA-125 concentrations of 75 ART cycles were measured 1 day before and on the day of human chorionic gonadotrophin (HCG) administration, and on the day of oocyte retrieval, These women did not have endometriosis and were induced by long-protocol gonadotrophin-releasing hormone analogue. Pregnancy was achieved in 35 (46.7%) cycles, but not in 40 cycles (53.3%), Serum CA-125 concentrations 1 day before and on the day of HCG administration and on the day of oocyte retrieval were significantly higher in cycles with pregnancy than in those without pregnancy (P < 0.05), It was noted that CA-125 concentrations on the day of oocyte retrieval were the best predictors of pregnancy, with concentrations > 10 IU/ml having an accuracy of 86.6% for pregnancy. In conclusion, in intracytoplasmic sperm injection cycles, women with high serum CA-125 concentrations (> 10 IU/ml) on the day of oocyte retrieval had very high pregnancy rates.en_US
dc.identifier.doi10.1093/humrep/16.6.1129en_US
dc.identifier.endpage1134en_US
dc.identifier.issn0268-1161
dc.identifier.issue6en_US
dc.identifier.pmid11387281en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1129en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/16.6.1129
dc.identifier.urihttps://hdl.handle.net/11454/35766
dc.identifier.volume16en_US
dc.identifier.wosWOS:000169274900014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectassisted reproduction treatmentsen_US
dc.subjectCA-125en_US
dc.subjectendometriumen_US
dc.subjectpregnancyen_US
dc.subjectreceptivityen_US
dc.titleValue of serum CA-125 concentrations as predictors of pregnancy in assisted reproduction cyclesen_US
dc.typeArticleen_US

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