The predictive value of estradiol response after human chorionic gonadotropin administration on the outcome in IVF-ET cycles
Küçük Resim Yok
Tarih
2003
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: İn-vitro fertilizasyon embryo transferi(IVF-ET) sikluslannda human chorionic gondotropin (HCG) uygulandıktan sonra estradiol (E2) oranlarında gözlenen değişim derecesine göre fertilizasyon oranlarının ve gebelik oranlarının etkilenip etkilenmediğini araştırmak. Çalışmanın Yapıldığı Yer: Ege Üniversitesi, Aile Planlaması, İnfertilite Araştırma ve Uygulama Merkezi, Bornova, İzmir Materyal ve Method: IVF-ET uygulanan 248 olgu çalışma kapsamına alındı. Hastalar HCG uygulama öncesi ve sonrasında ölçülen estradiol seviyelerinin oranlanmasına göre sınıflandırılarak E2 düzeyi %10'dan fazla artanlar grup-1, E2 seviyesi öncekine göre %10'dan daha az artan yada azalanlar grup-2 ve E2 düzeyi öncekine göre %10'dan fazla düşenler grup-3 olmak üzere 3 gruba ayrıldı. Gruplarda, alınan oositlerin kaliteleri, fertilizasyon oranlan ve klinik gebelik oranları karşılaştırıldı. Bulgular: Gruplar arasında elde edilen ortalama metafaz-II oosit sayılarında anlamlı fark yoktu (sırasıyla; 7.4, 8.3, 8.5), (p=0.248). Fertilizasyon oranları her üç grupta da benzerdi; (sırasıyla; %76, %78, %80). Klinik gebelik o-ranları gruplarda sırasıyla %35.0 (50/143), %32.9 (26/79) ve %30.8 (8/26) bulundu ve istatistiksel olarak anlamlı değildi. Sonuç: Çalışma grubumuzda elde edilen sonuçlara göre IVF-ET sikluslannda HCG uygulaması sonrası E2 seviyesinde meydana gelen değişiklikler ile oosit kalitesi, fertilizasyon oranları ve klinik gebelik oranları arasında korelasyon saptanamadı.
Objective: To analyse the effect of the changes in serum estradiol (E2) concentrations after human chorionic gonadotopin administration(HCG) on fertilization rate and pregnancy rate in in-vitro fertilization embryo transfer(IVF-ET) cycles. Setting: Ege University, Family Planning, Infertility Research and Treatment Center, Bornova, İzmir, Turkey Matherial and Method: Two-hundred-forty-eight patients who had undergone IVF-ET were enrolled into the study. the patients were grouped according to the ratio of serum E2 levels before and after HCG administration; group-1 consisted of the patients who had an increase in E2 of >10%, group-2 with E2 levels remained between a gain and loss of 10%, and group-3 responders exhibited a >10% decrease in their E2 levels after HCG. the primary outcome measures included the oocyte quality, the fertilization rates and the clinical pregnancy rates. Results: There was no difference in terms of the mean number of metaphase-II oocytes picked up among the groups (7.4, 8.3, 8.5, repectively),(p=0.248). the fertilization rates in group-1, group-2, and group-3 were found to be similar(76%, 78%, 80%, respectively),(p=0,833). the clinical pregnancy rates in group-1, group-2, and group-3 were 35.0% (50/143), 32.9.0% (26/79), and 30.8% (8/26), respectively and there was no statistically significant difference (p=0.896). Conclusion: in our study population, the results do not ascribe any predictive significance of E2 response after HCG administration to oocyte quality, fertilization rates and clinical pregnancy rates in IVF-ET cycles.
Objective: To analyse the effect of the changes in serum estradiol (E2) concentrations after human chorionic gonadotopin administration(HCG) on fertilization rate and pregnancy rate in in-vitro fertilization embryo transfer(IVF-ET) cycles. Setting: Ege University, Family Planning, Infertility Research and Treatment Center, Bornova, İzmir, Turkey Matherial and Method: Two-hundred-forty-eight patients who had undergone IVF-ET were enrolled into the study. the patients were grouped according to the ratio of serum E2 levels before and after HCG administration; group-1 consisted of the patients who had an increase in E2 of >10%, group-2 with E2 levels remained between a gain and loss of 10%, and group-3 responders exhibited a >10% decrease in their E2 levels after HCG. the primary outcome measures included the oocyte quality, the fertilization rates and the clinical pregnancy rates. Results: There was no difference in terms of the mean number of metaphase-II oocytes picked up among the groups (7.4, 8.3, 8.5, repectively),(p=0.248). the fertilization rates in group-1, group-2, and group-3 were found to be similar(76%, 78%, 80%, respectively),(p=0,833). the clinical pregnancy rates in group-1, group-2, and group-3 were 35.0% (50/143), 32.9.0% (26/79), and 30.8% (8/26), respectively and there was no statistically significant difference (p=0.896). Conclusion: in our study population, the results do not ascribe any predictive significance of E2 response after HCG administration to oocyte quality, fertilization rates and clinical pregnancy rates in IVF-ET cycles.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türkiye Klinikleri Jinekoloji Obstetrik Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
6
