Live birth after frozen-thawed embryo transfer: which endometrial preparation protocol is better?

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dc.contributor.authorSahin, Gulnaz
dc.contributor.authorAcet, Ferruh
dc.contributor.authorCalimlioglu, Nilufer
dc.contributor.authorMeseri, Reci
dc.contributor.authorGoker, Ege Nazan Tavmergen
dc.contributor.authorTavmergen, Erol
dc.date.accessioned2020-12-01T11:57:57Z
dc.date.available2020-12-01T11:57:57Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To compare the clinical outcomes of modified natural cycle (mNC) and artificial cycle (AC) protocols for frozen embryo transfers. Material and methods: A total of 490 frozen-thawed autologous embryo transfer cycles, performed in a single tertiary IVF center, between January 2015 and September 2017, were retrospectively analyzed. of these, 214 cycles were performed after mNC and 276 cycles were performed after gonadotrophin-releasing hormone (GnRH) agonist plus sequential estrogen and progestin priming protocol. the primary outcome was live birth and secondary outcomes were clinical pregnancy, implantation and miscarriage rates. Multivariate regression analysis was used to adjust covariates on clinical outcome. Results: the rates of live birth (33.6 % vs. 29.3 %, respectively), clinical pregnancy (40.2 % vs. 36.6 %, respectively), implantation (32.3 % vs. 28.5 %, respectively), and miscarriage (5.1 % vs. 6.9 %, respectively) were not different between the mNC and AC groups. Multivariate analysis also showed that the method for endometrial preparation had no significant effect on clinical pregnancy and live birth. the adjusted odds ratios (OR) of live births and clinical pregnancies were 0.97 (95 % CI 0.64-1.48) and 0.98 (95 % CI 0.65-1.46) for the AC compared to mNC group. However, there was a significant difference between mNC and AC in cycles in which double embryo transfer was performed. the live birth (48 % vs. 31.4 %P = 0.01) and clinical pregnancy rates (53.9 % vs. 38.8 %, P = 0.02) were significantly higher in the mNC group than the AC group for double embryo transfers. Conclusion: the live birth and clinical pregnancy rates are comparable between mNC and AC with GnRH agonists in frozen thawed embryo transfer cycles. in ovulatory patients with planned double embryo transfer, mNC can be considered. Further well-designed prospective studies are needed to confirm our results. (C) 2020 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.jogoh.2020.101782en_US
dc.identifier.issn2468-7847
dc.identifier.issn1773-0430
dc.identifier.issue8en_US
dc.identifier.pmid32360633en_US
dc.identifier.scopus2-s2.0-85084679435en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jogoh.2020.101782
dc.identifier.urihttps://hdl.handle.net/11454/61878
dc.identifier.volume49en_US
dc.identifier.wosWOS:000576306100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corp Offen_US
dc.relation.ispartofJournal of Gynecology Obstetrics and Human Reproductionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArtificial cycleen_US
dc.subjectEndometrial preparationen_US
dc.subjectfrozen-thawed embryo transferen_US
dc.subjectLive birth ratesen_US
dc.subjectModified natural cycleen_US
dc.titleLive birth after frozen-thawed embryo transfer: which endometrial preparation protocol is better?en_US
dc.typeArticleen_US

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