An index to prevent major limb amputations in diabetic foot

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dc.authorscopusid58247520300
dc.authorscopusid58246684600
dc.authorscopusid35574673900
dc.authorscopusid6505803191
dc.contributor.authorZengin, B.
dc.contributor.authorYuzuguldu, B.
dc.contributor.authorSimsir, I.Y.
dc.contributor.authorCetinkalp, S.
dc.date.accessioned2024-08-25T18:38:55Z
dc.date.available2024-08-25T18:38:55Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Besides the early detection and treatment of diabetic foot ulcers, being aware of the risk factors for major amputation plays a crucial role in preventing the major lower limb amputations. Major lower limb amputations are not just mentally and physically hard for patients, but also have an effect on patient's survival and are a financial burden on both patients and healthcare systems. Subjects and Methods. We defined 37 potential risk factors for major amputation and these risk factors were investigated among 507 patients who had ulcers in their feet and were seen by the diabetic foot ulcer council at Ege University Faculty of Medicine. In our study, 106 (20.9%) patients ended up undergoing major lower limb amputation. Results. The univariate analysis showed that 24 defined risk factors were statistically significant. In the multivariate analysis using the Cox regression model, 6 risk factors remained statistically significant. Multivariate-adjusted hazard ratios were 4.172 for hyperlipidemia, 3.747 for albumin <3.365 g/dL, 3.368 for C-reactive protein (CRP) >2.185 mg/L, 2.067 for presence of gangrenous Wagner stage, 1.931 for smoking tobacco >30 pack/year, and 1.790 for hematocrit (HCT) <31.5%. Most patients with major amputation presented with a neuroischemic foot (58%). Gender and age were not found to be risk factors for major amputation. Having less than 7% of hemoglobin A1c (HbA1c) levels had a direct proportion with major amputation numbers. The mortality rates in one year, two and three years after the major amputation operations were 24.6%, 30%, and 35.9%, respectively. Conclusion. Being familiar with these risk factors for major amputation is crucial for multi-disciplinary teams to take good care of patients with diabetic foot ulcers and to lower the need for major amputations. © 2023 Bugra Zengin et al., published by Sciendo.en_US
dc.identifier.doi10.2478/enr-2023-0010
dc.identifier.endpage91en_US
dc.identifier.issn1210-0668
dc.identifier.issue1en_US
dc.identifier.pmid37183692en_US
dc.identifier.scopus2-s2.0-85159198205en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.2478/enr-2023-0010
dc.identifier.urihttps://hdl.handle.net/11454/101190
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofEndocrine Regulationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectdiabetic foot ulceren_US
dc.subjectmajor amputationen_US
dc.subjectpredictionen_US
dc.subjectpreventionen_US
dc.subjectalbuminen_US
dc.subjectC reactive proteinen_US
dc.subjecthemoglobin A1cen_US
dc.subjectC reactive proteinen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectcaregiveren_US
dc.subjectcohort analysisen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectdiabetic footen_US
dc.subjectdialysisen_US
dc.subjectfemaleen_US
dc.subjectfinancial stressen_US
dc.subjectfoot careen_US
dc.subjectgangreneen_US
dc.subjecthealth care systemen_US
dc.subjecthematocriten_US
dc.subjecthematological parametersen_US
dc.subjecthospitalizationen_US
dc.subjecthumanen_US
dc.subjecthypercholesterolemiaen_US
dc.subjecthyperglycemiaen_US
dc.subjecthyperlipidemiaen_US
dc.subjectinsulin dependent diabetes mellitusen_US
dc.subjectlimb amputationen_US
dc.subjectlower limben_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectmortality rateen_US
dc.subjectmultivariate analysisen_US
dc.subjectnon insulin dependent diabetes mellitusen_US
dc.subjectperipheral arterial diseaseen_US
dc.subjectpredictionen_US
dc.subjectprophylaxisen_US
dc.subjectproportional hazards modelen_US
dc.subjectreceiver operating characteristicen_US
dc.subjectretrospective studyen_US
dc.subjectrisk factoren_US
dc.subjectsmokingen_US
dc.subjectsurvival rateen_US
dc.subjecttobaccoen_US
dc.subjectunivariate analysisen_US
dc.subjectamputationen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdiabetic footen_US
dc.subjectAmputation, Surgicalen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Footen_US
dc.subjectHumansen_US
dc.subjectRetrospective Studiesen_US
dc.subjectRisk Factorsen_US
dc.titleAn index to prevent major limb amputations in diabetic footen_US
dc.typeArticleen_US

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