Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Verlag
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Ursodeoxycholic acid is frequently used in cholestatic liver diseases. Also, it protects hepatocytes against oxidative stress induced by hydrophobic bile acids. We investigated the anti-oxidative effect of ursodeoxycholic acid on ischemia/reperfusion injury after ovarian de-torsion in rats. Methods: We designed five study groups. Group 1 (n = 6): Sham-operated group; group 2 (n = 6): torsion group; group 3 (n = 6): torsion and ursodeoxycholic acid, group 4 (n = 7): torsion/de-torsion group; and group 5 (n = 7): torsion/de-torsion and ursodeoxycholic acid. After that, ovarian samples were obtained and examined histologically and tissue levels of malondialdehyde were measured. Results: Follicular degeneration, edema and inflammatory cells were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Also, groups 4 and 5 were compared in terms of vascular congestion and hemorrhage and these were found to be significantly decreased in group 5. In addition, levels of malondialdehyde were significantly decreased in groups 3 and 5 in comparison with groups 2 and 4. Conclusions: We concluded that ursodeoxycholic acid might be useful to protect the ovary against ischemia and reperfusion injury. © 2015, Springer-Verlag Berlin Heidelberg.
Açıklama
Anahtar Kelimeler
Ischemia/reperfusion injury, Ovarian torsion, Oxidative stress, Ursodeoxycholic acid
Kaynak
Archives of Gynecology and Obstetrics
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
292
Sayı
2
