Cardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysis

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dc.authorscopusid57206938007
dc.authorscopusid57216292998
dc.authorscopusid57222745382
dc.authorscopusid57200652121
dc.authorscopusid24479281000
dc.authorscopusid23393080500
dc.authorscopusid57203046227
dc.contributor.authorGalimzhanov, A.
dc.contributor.authorIstanbuly, S.
dc.contributor.authorTun, H.N.
dc.contributor.authorOzbay, B.
dc.contributor.authorAlasnag, M.
dc.contributor.authorKy, B.
dc.contributor.authorLyon, A.R.
dc.date.accessioned2024-08-25T18:48:12Z
dc.date.available2024-08-25T18:48:12Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAIMS: It is unclear whether the future risk of cardiovascular events in breast cancer (Bc) survivors is greater than in the general population. This meta-analysis quantifies the risk of cardiovascular disease development in Bc patients, compared to the risk in a general matched cancer-free population, and reports the incidence of cardiovascular events in patients with Bc. METHODS AND RESULTS: We searched PubMed, Scopus, and Web of Science databases (up to 23 March 2022) for observational studies and post hoc analyses of randomized controlled trials. Cardiovascular death, heart failure (HF), atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), and stroke were the individual endpoints for our meta-analysis. We pooled incidence rates (IRs) and risk in hazard ratios (HRs), using random-effects meta-analyses. Heterogeneity was reported through the I2 statistic, and publication bias was examined using funnel plots and Egger's test in the meta-analysis of risk. One hundred and forty-two studies were identified in total, 26 (836 301 patients) relevant to the relative risk and 116 (2 111 882 patients) relevant to IRs. Compared to matched cancer-free controls, Bc patients had higher risk for cardiovascular death within 5 years of cancer diagnosis [HR = 1.09; 95% confidence interval (CI): 1.07, 1.11], HF within 10 years (HR = 1.21; 95% CI: 1.1, 1.33), and AF within 3 years (HR = 1.13; 95% CI: 1.05, 1.21). The pooled IR for cardiovascular death was 1.73 (95% CI 1.18, 2.53), 4.44 (95% CI 3.33, 5.92) for HF, 4.29 (95% CI 3.09, 5.94) for CAD, 1.98 (95% CI 1.24, 3.16) for MI, 4.33 (95% CI 2.97, 6.30) for stroke of any type, and 2.64 (95% CI 2.97, 6.30) for ischaemic stroke. CONCLUSION: Breast cancer exposure was associated with the increased risk for cardiovascular death, HF, and AF. The pooled incidence for cardiovascular endpoints varied depending on population characteristics and endpoint studied. REGISTRATION: CRD42022298741. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.This work investigated the absolute and relative risk of cardiovascular outcomes in breast cancer survivors. Breast cancer was associated with a higher risk of cardiovascular death, heart failure (HF), and atrial fibrillation when compared to the general population.The incidence for cardiovascular death, HF, and coronary artery disease were 1.73, 4.44, and 4.29 per 1000 person-years, respectively.Clinicians should carefully assess breast cancer survivors for their cardiovascular risk factor profile and monitor their cardiovascular function.en_US
dc.identifier.doi10.1093/eurjpc/zwad243
dc.identifier.endpage2031en_US
dc.identifier.issn2047-4881
dc.identifier.issue18en_US
dc.identifier.pmid37499186en_US
dc.identifier.scopus2-s2.0-85178385074en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2018en_US
dc.identifier.urihttps://doi.org/10.1093/eurjpc/zwad243
dc.identifier.urihttps://hdl.handle.net/11454/102187
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean journal of preventive cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBreast canceren_US
dc.subjectCardiovascular diseasesen_US
dc.subjectEpidemiologyen_US
dc.subjectHeart disease risk factorsen_US
dc.subjectIncidenceen_US
dc.subjectSystematic reviewen_US
dc.subjectatrial fibrillationen_US
dc.subjectbrain ischemiaen_US
dc.subjectbreast tumoren_US
dc.subjectcancer survivoren_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcerebrovascular accidenten_US
dc.subjectcomplicationen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectfemaleen_US
dc.subjectheart failureen_US
dc.subjectheart infarctionen_US
dc.subjecthumanen_US
dc.subjectmeta analysisen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectBrain Ischemiaen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCancer Survivorsen_US
dc.subjectCardiovascular Diseasesen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectFemaleen_US
dc.subjectHeart Failureen_US
dc.subjectHumansen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectStrokeen_US
dc.titleCardiovascular outcomes in breast cancer survivors: a systematic review and meta-analysisen_US
dc.typeArticleen_US

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