Long-term Dental Anomalies after Pediatric Cancer Treatment in Children

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dc.contributor.authorKilinc, Gulser
dc.contributor.authorBulut, Gulcin
dc.contributor.authorErtugrul, Fahinur
dc.contributor.authorOren, Hale
dc.contributor.authorDemirag, Bengu
dc.contributor.authorDemiral, Ayse
dc.contributor.authorAksoylar, Serap
dc.contributor.authorKernel, Emine Serra
dc.contributor.authorEllidokuz, Hulya
dc.contributor.authorOlgun, Nur
dc.date.accessioned2019-10-27T09:47:21Z
dc.date.available2019-10-27T09:47:21Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to determine the frequency of dental anomalies (DAs) (microdontia, hypodontia, hyperdontia, enamel defect, root malformation) in pediatric cancer patients at the ages <5 years and between 5 and 7 years, and understand their relationship with the received therapy. Materials and Methods: Pediatric patients who were diagnosed with cancer and treated before the age of 7 years were investigated in a case-control design. The study included 93 pediatric patients whose ages at diagnosis were between 9 months and 7 years and whose treatments were completed before 5-8 years. Group A consisted of patients in the age range of 9 months to 4 years and Group B consisted of patients in the age range of 5-7 years. Seventy-two siblings with compatible dental age ranges were included in the control group. For both groups, intraoral examinations were performed and panoramic radiographs were taken. Results: Among the 93 pediatric patients, the mean age was 9.54 +/- 1.25 (range: 8-13 years) and 48 (51.6%) patients were male. The most common diagnosis was hematologic malignancy with a rate of 65.5%. At least one DA was detected in 7 (9.7%) individuals of the control group and in 78 (83.9%) of the patient group. While the patients in the study group had all kinds of DAs, those in the control group had only enamel defects. The rates of microdontia (p=0.077) and hypodontia (p=0.058) were detected to be significantly higher in Group A than in Group B. Root malformation was more common in patients receiving chemotherapy and radiotherapy than in those receiving only chemotherapy (p=0.006). Conclusion: In this study it was found that the pediatric patients who received cancer treatment before the age of 7 years constituted a high-risk group for DAs. The frequencies of microdontia and hypodontia were increased even more when the patient was treated for cancer before 5 years of age.en_US
dc.identifier.doi10.4274/tjh.galenos.2018.2018.0248en_US
dc.identifier.endpage161en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid30322830en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2018.2018.0248
dc.identifier.urihttps://hdl.handle.net/11454/29394
dc.identifier.volume36en_US
dc.identifier.wosWOS:000482629200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCanceren_US
dc.subjectChildrenen_US
dc.subjectDental anomaliesen_US
dc.subjectHypodontiaen_US
dc.subjectMicrodontiaen_US
dc.subjectRoot malformationen_US
dc.subjectEnamel defecten_US
dc.titleLong-term Dental Anomalies after Pediatric Cancer Treatment in Childrenen_US
dc.typeArticleen_US

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