The effects of early or late treatment of osteochondral defects on joint homoeostasis: an experimental study in rabbits

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dc.contributor.authorOzsoy, Mehmet Hakan
dc.contributor.authorAydogdu, Semih
dc.contributor.authorTaskiran, Dilek
dc.contributor.authorSezak, Murat
dc.contributor.authorHayran, Mutlu
dc.contributor.authorOztop, Fikri
dc.contributor.authorOzsoy, Arzu
dc.date.accessioned2019-10-27T20:51:41Z
dc.date.available2019-10-27T20:51:41Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractA 3.5 x 4 mm tubular osteochondral defect was created on the right medial femoral condyles of 51 adult rabbits. In the control group (CG), defects were left untreated. In the early-(ETG) and late-(LTG) treatment groups, defects were treated by an osteoperiosteal graft 1 and 12 weeks, respectively, after the index procedure. Synovial fluid (SF) samples were collected regularly and proteoglycan fragments (PF), total collagen (TC) and collagenase (MMP-1) levels were measured. Rabbits were killed at 4 (early period), 12 (intermediate period), or 24 (late period) weeks postoperatively. Histological examination indicated a more successful healing in both grafting groups than in the CG, but without any difference at any time period between the grafting groups. In the CG, PF, and TC levels in SF increased continuously until the late period, indicating an ongoing degenerative activity in the joints. In contrast, SF marker levels in both grafting groups indicated that normalization in joint metabolism could be achieved-at least partially-after treatment. However, PF levels in the SF showed that the treatment of defects in earlier stages might result in better outcomes since the negative effects were more prominent in chronic stages, presumably due to the more prolonged period of disturbed homeostasis. Thus, histological values and SF marker levels indicated that treatment of osteochondral defects at any time of the disease had a positive effect on healing when compared to no treatment. Early treatment might better assist the recovery of joint homeostasis than late treatment.en_US
dc.description.sponsorshipEge University Research FundEge University [98/TIP/006]; Ege University Science and Technology CenterEge Universityen_US
dc.description.sponsorshipWe thank Dr. Emin Taskiran and Dr. Veli Lok for their helpful suggestions in planning this research. All authors declare that these experiments comply with the current laws of our country. We also want to acknowledge financial support from Ege University Research Fund (Research Project No: 98/TIP/006) and Ege University Science and Technology Center, Co-funding of Research Projects Programme.en_US
dc.identifier.doi10.1007/s00167-008-0675-yen_US
dc.identifier.endpage589en_US
dc.identifier.issn0942-2056
dc.identifier.issn1433-7347
dc.identifier.issue6en_US
dc.identifier.pmid19083207en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://doi.org/10.1007/s00167-008-0675-y
dc.identifier.urihttps://hdl.handle.net/11454/43140
dc.identifier.volume17en_US
dc.identifier.wosWOS:000266482200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofKnee Surgery Sports Traumatology Arthroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKneeen_US
dc.subjectOsteochondral lesionen_US
dc.subjectHomeostasisen_US
dc.subjectSynovial fluid markeren_US
dc.subjectProteoglycan fragmenten_US
dc.subjectTotal collagenen_US
dc.subjectMMP-1en_US
dc.titleThe effects of early or late treatment of osteochondral defects on joint homoeostasis: an experimental study in rabbitsen_US
dc.typeArticleen_US

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