Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results

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dc.contributor.authorIlgenli, T
dc.contributor.authorAtilla, G
dc.contributor.authorBaylas, H
dc.date.accessioned2019-10-27T18:25:19Z
dc.date.available2019-10-27T18:25:19Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Drug-induced gingival overgrowth (DGO) is one of the well-recognized side effects of cyclosporin A (CsA) or nifedipine (Ni). After surgical periodontal therapy, the incidence of DGO recurrence is not known. The aim of this study was to evaluate the results of surgical periodontal therapy in patients receiving CsA or Ni and who exhibit severe long-term DGO. In addition, the relationship between various variables and the recurrence of severe DGO after periodontal surgery was investigated. Methods: A total of 38 patients, 22 with CsA-induced DGO and 16 with Ni-induced DGO, were included in this study. At baseline, patients received initial periodontal therapy, after which either the upper or lower anterior segment in each patient was surgically treated. Surgical periodontal therapy consisted of the flap technique with a 90 degrees gingivectomy incision. Following surgery, patients were placed on a maintenance therapy recall program and were monitored for 18 months. Patients were seen once a month for the first 3 months and once every 3 months for the following 15 months, Plaque index (PI), papilla bleeding index (PBI) and DGO scores in the treated segments were recorded at each recall appointment. Attendance at recall appointments was also noted for each patient. Results: Recurrence of severe DGO was observed in 13 of the 38 patients (34%) 18 months following periodontal surgery. Multiple regression analysis indicated that age, gingival inflammation, and attendance at recall appointments were significant determinants of the recurrence of severe DGO. Conclusions: This study suggests that regular re-motivation and professional care at frequent recall appointments after periodontal surgery are of great importance in patients receiving CsA or Ni. By maintaining periodontal health, the life quality of these patients may be raised.en_US
dc.identifier.doi10.1902/jop.1999.70.9.967en_US
dc.identifier.endpage972en_US
dc.identifier.issn0022-3492
dc.identifier.issue9en_US
dc.identifier.pmid10505798en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage967en_US
dc.identifier.urihttps://doi.org/10.1902/jop.1999.70.9.967
dc.identifier.urihttps://hdl.handle.net/11454/36289
dc.identifier.volume70en_US
dc.identifier.wosWOS:000082644500003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Acad Periodontologyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgingival hyperplasia/etiologyen_US
dc.subjectgingival hyperplasia/prevention and controlen_US
dc.subjectgingival hyperplasia/surgeryen_US
dc.subjectcyclosporin A/adverse effectsen_US
dc.subjectnifedipine/adverse effectsen_US
dc.subjectfollow-up studiesen_US
dc.titleEffectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term resultsen_US
dc.typeArticleen_US

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