Severe colitis after administration of UFT chemotherapy for temporal bone carcinoma

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dc.contributor.authorAkay S.
dc.contributor.authorÖzütemiz Ö.
dc.contributor.authorDoganavsargil B.
dc.date.accessioned2019-10-27T00:22:40Z
dc.date.available2019-10-27T00:22:40Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractUFT (Uftoral®), a blend of uracil and Tegafur, is an antitumour agent for oral administration that is presumed to maintain the concentration of 5-fluorouracil (5-FU) in tumour tissue. As a result of increased use of high-dose 5-FU-based chemotherapy for various solid tumours, complicated drug-induced colitis is more frequently observed. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the catabolism of 5-FU and its deficiency is responsible for the severe toxicities encountered in cancer patients receiving 5-FU. The authors present the case of a patient with locally advanced temporal bone carcinoma who developed haematochezia during a course of chemotherapy with UFT. Colonoscopy of the patient showed bleeding petechia-like lesions and superficial inflammatory exudate, whilst histology revealed non-specific inflammatory changes of the colon mucosa. As the haematochezia improved with supportive treatment, neutropenia complicated the clinical picture. This patient developed life-threatening UFT toxicity without an exon-14 DPD gene mutation. 2004 © Ashley Publications Ltd.en_US
dc.identifier.doi10.1517/14740338.3.2.89en_US
dc.identifier.endpage92en_US
dc.identifier.issn1474-0338
dc.identifier.issue2en_US
dc.identifier.pmid15006714en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1517/14740338.3.2.89
dc.identifier.urihttps://hdl.handle.net/11454/22627
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofExpert Opinion on Drug Safetyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColitisen_US
dc.subjectDihydropyrimidine dehydrogenase (DPD) deficiencyen_US
dc.subjectGastrointestinal (GI) side effectsen_US
dc.subjectUFTen_US
dc.titleSevere colitis after administration of UFT chemotherapy for temporal bone carcinomaen_US
dc.typeArticleen_US

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