Beta-thalassemia major: Plasma cytokine ( IL-3 , IL-7 ) concentrations regulating immune response and erythropoiesis

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dc.contributor.authorCanan Vergin
dc.contributor.authorNecil Kütükçüler
dc.contributor.authorKaan Kavaklı
dc.contributor.authorNazan Çetingül
dc.contributor.authorŞenay Öztop
dc.contributor.authorGüngör Nişli
dc.contributor.authorSuat Çağlayan
dc.date.accessioned2019-10-26T20:03:54Z
dc.date.available2019-10-26T20:03:54Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractPlasma levels of ILr3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines involved in previously defined abnormalities in erythropoiesis and immune response for this dis¬ease. No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not involved in cellular immunological alterations in beta-thalassemia. However, the number of thalassemic patients with detectable IL-3 concentrations was significantly higher. The data related with HbF and IL-3 showed a positive correlation and three of the patients had the highest levels of both IL-3 and HbF. It was conclud¬ed that IL-3 production has to be studied in detail in order to learn more about the involvement of this cytokine in erythro¬poiesis of thalassemic patients. Turk J Haematol 1997; 14:97-100.en_US
dc.description.abstractPlasma levels of ILr3 and IL-7 were studied in 23 patients with homozygous beta-thalassemia in order to determine whether these cytokines involved in previously defined abnormalities in erythropoiesis and immune response for this dis¬ease. No significant difference was found in plasma IL-7 concentrations between thalassemic patients and healthy controls and it was suggested that IL-7 is not involved in cellular immunological alterations in beta-thalassemia. However, the number of thalassemic patients with detectable IL-3 concentrations was significantly higher. The data related with HbF and IL-3 showed a positive correlation and three of the patients had the highest levels of both IL-3 and HbF. It was conclud¬ed that IL-3 production has to be studied in detail in order to learn more about the involvement of this cytokine in erythro¬poiesis of thalassemic patients. Turk J Haematol 1997; 14:97-100.en_US
dc.identifier.endpage100en_US
dc.identifier.issn1300-7777
dc.identifier.issue3en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRNeE5qVTE=
dc.identifier.urihttps://hdl.handle.net/11454/14646
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHematolojien_US
dc.titleBeta-thalassemia major: Plasma cytokine ( IL-3 , IL-7 ) concentrations regulating immune response and erythropoiesisen_US
dc.typeOtheren_US

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