The effect of platelet-rich plasma on motility changes in experimental caustic esophageal burn

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dc.contributor.authorOztan, Mustafa Onur
dc.contributor.authorOztan, Sule
dc.contributor.authorDuzenli, Neslihan
dc.contributor.authorOlukman, Murat
dc.contributor.authorKoyluoglu, Gokhan
dc.date.accessioned2019-10-27T10:04:39Z
dc.date.available2019-10-27T10:04:39Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBesides stricture formation, diminished esophageal motility after caustic esophageal burns also plays a role in the deterioration of the clinical course. In this study, we aimed to investigate the effect of caustic burn on the esophageal contractions and the effect of platelet-rich plasma (PRP) on these changes. Twenty-one Wistar albino rats were divided into three groups [Sham operation (n = 8), caustic esophageal burn with NaOH (n = 6), PRP treatment after caustic burn (n = 7)]. After 3 weeks, esophagectomy was performed and contractions and EFS responses were evaluated in the organ bath. KCl- and acetylcholine-induced responses were reduced in the Burn group, but increased in Sham and PRP groups (p < 0.05). EFS responses were higher in Burn group compared to the other groups. Response with l-arginine was increased in Burn group, but decreased in PRP group. There was more decrease in the contraction in Sham and PRP groups compared to the Burn group after SNP (sodium nitroprusside) incubation (p < 0.05). L-NAME (N omega-Nitro-l-arginine methyl ester) did not change the EFS responses in the Burn group, but EFS responses were decreased significantly in Sham and PRP groups (p < 0.05). EFS responses were decreased in all groups, but more in the Sham and PRP groups after Y-27632 (Rho-kinase inhibitor) incubation (p < 0.05). For the first time, we demonstrated that both cholinergic and non-adrenergic non-cholinergic mechanisms are responsible for the altered motility in corrosive esophageal injury. Our results suggest that PRP treatment may be helpful in regulating the esophageal motility and decreasing altered contractions in corrosive burns. This effect may also contribute to the reduction of stricture formation, especially by reducing inappropriate contractions of the esophageal wall during the post-burn healing phase.en_US
dc.description.sponsorshipScientific Research Fund of Katip Celebi University [2016-0027]en_US
dc.description.sponsorshipThe financial support for this study is provided from the Scientific Research Fund of Katip Celebi University (Project number: 2016-0027).en_US
dc.identifier.doi10.1007/s10388-018-0613-0en_US
dc.identifier.endpage204en_US
dc.identifier.issn1612-9059
dc.identifier.issn1612-9067
dc.identifier.issue3en_US
dc.identifier.pmid29951983en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1007/s10388-018-0613-0
dc.identifier.urihttps://hdl.handle.net/11454/30264
dc.identifier.volume15en_US
dc.identifier.wosWOS:000436571400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofEsophagusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaustic burnen_US
dc.subjectEsophageal motilityen_US
dc.subjectNon-adrenergic non-cholinergic systemen_US
dc.subjectPlatelet-rich plasmaen_US
dc.titleThe effect of platelet-rich plasma on motility changes in experimental caustic esophageal burnen_US
dc.typeArticleen_US

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