Cholesterol levels in patients with multiple myeloma

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dc.contributor.authorYavasoglu, Irfan
dc.contributor.authorTombuloglu, Murat
dc.contributor.authorKadikoylu, Gurhan
dc.contributor.authorDonmez, Ayhan
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorBolaman, Zahit
dc.date.accessioned2019-10-27T19:54:52Z
dc.date.available2019-10-27T19:54:52Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractHypocholesterolemia is seen in solid tumors and some hematological malignancies. We assessed cholesterol levels and the relationship between these levels and types and stages of multiple myeloma (MM) in the patients with MM. One-hundred two patients (60 male and 42 female) of mean age 59 +/- 11 years with MM were enrolled to this study. While 71.6% of the patients were Ig G type, 80.4% of the patients were at stage III. In the control group, there were 71 healthy persons (42 male and 29 female) of mean age 58 +/- 8 years. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in the patients with MM were significantly lower than the controls (p<0.001). There was no difference for the levels of very-low-density lipoprotein cholesterol and triglyceride between the two groups (p>0.05). Lipid parameters were not different between Ig types (p>0.05). The levels of TC and LDL-C in the patients with stage I were higher than those of stages II and III (p<0.001 and p<0.005, respectively). The levels of TC and LDL-C in the controls were not higher than the patients with stage I (p>0.05). HDL-C levels in the patients with stage III were lower than controls (p<0.001). Hypocholesterolemia are seen in the patients with MM. Hypocholesterolemia may be due to increased LDL clearance and utilization of cholesterol by myeloma cells.en_US
dc.identifier.doi10.1007/s00277-007-0375-6en_US
dc.identifier.endpage228en_US
dc.identifier.issn0939-5555
dc.identifier.issn1432-0584
dc.identifier.issue3en_US
dc.identifier.pmid17874102en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1007/s00277-007-0375-6
dc.identifier.urihttps://hdl.handle.net/11454/40584
dc.identifier.volume87en_US
dc.identifier.wosWOS:000252538900007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcholesterol levelsen_US
dc.subjectmultiple myelomaen_US
dc.titleCholesterol levels in patients with multiple myelomaen_US
dc.typeArticleen_US

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