Metachromatic leukodystrophy. Diffusion MR imaging and proton MR spectroscopy

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dc.contributor.authorSener R.N.
dc.date.accessioned2019-10-27T08:59:40Z
dc.date.available2019-10-27T08:59:40Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractMetachromatic leukodystrophy is characterized by dysmyelination caused by a deficiency of arylsulfatase-A. In a 17-month-old boy with metachromatic leukodystrophy, an echo-planar diffusion MR sequence revealed a restricted diffusion pattern in the deep white matter, manifested by high-signal on b = 1000 s/mm2 images, and low ADC values (0.56 × 10 -3mm2/s). Proton MR spectroscopy revealed a marked decrease in choline, a metabolite related to myelin turnover. These observations consisting of a restricted diffusion pattern on diffusion MR imaging, and decreased choline peaks on proton spectroscopy, likely represented dysmyelination in metachromatic leukodystrophy.en_US
dc.identifier.doi10.1034/j.1600-0455.2003.00094.xen_US
dc.identifier.endpage443en_US
dc.identifier.issn0284-1851
dc.identifier.issue4en_US
dc.identifier.pmid12846696en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage440en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-0455.2003.00094.x
dc.identifier.urihttps://hdl.handle.net/11454/27874
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Radiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiffusion MR imagingen_US
dc.subjectMetachromatic leukodystrophyen_US
dc.subjectProton MR spectroscopyen_US
dc.titleMetachromatic leukodystrophy. Diffusion MR imaging and proton MR spectroscopyen_US
dc.typeArticleen_US

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