Toxicity of Cephalaria Species and their Individual Constituents against Aedes aegypti

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dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorKayce, Peyker
dc.contributor.authorTabanca, Nurhayat
dc.contributor.authorEstep, Alden S.
dc.contributor.authorBecnel, James J.
dc.contributor.authorKhan, Ikhlas A.
dc.contributor.authorKirmizigul, Suheyla
dc.date.accessioned2019-10-27T20:23:53Z
dc.date.available2019-10-27T20:23:53Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractCrude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. elazigensis var. purpurea, C. anatolica, and C. elmaliensis possessed the highest mortality against first instar Ae. aegypti larvae. Luteolin-7-O-beta-D-glycoside (1), isolated from C. elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 mu g/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 mu g/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.en_US
dc.description.sponsorshipResearch Grant Office of Ege University Izmir-TurkeyEge University [2013/Fen/035]; USDA-ARS - U.S. Department of Defense through the Armed Forces Pest Management Board [56-6402-1-612]en_US
dc.description.sponsorshipThis study was supported in part by Research Grant Office of Ege University Izmir-Turkey (2013/Fen/035) and USDA-ARS grant No. 56-6402-1-612, Deployed War-Fighter Protection Research Program Grant funded by the U.S. Department of Defense through the Armed Forces Pest Management Board. Thanks are also due to Prof. Dr H. Sumbul and Assoc. Prof. Dr R. S. Gokturk for collection and identification of the plants and J. Louton, for mosquito bioassaysen_US
dc.identifier.endpage1198en_US
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.issue7en_US
dc.identifier.pmid26411009en_US
dc.identifier.startpage1195en_US
dc.identifier.urihttps://hdl.handle.net/11454/42069
dc.identifier.volume10en_US
dc.identifier.wosWOS:000359095700015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatural Products Incen_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCephalaria speciesen_US
dc.subjectLarvidical activityen_US
dc.subjectAdult topical activityen_US
dc.subjectAedes aegyptien_US
dc.subjectMosquito controlen_US
dc.subjectFlavonoid glycosidesen_US
dc.subjectIridoid glycosidesen_US
dc.titleToxicity of Cephalaria Species and their Individual Constituents against Aedes aegyptien_US
dc.typeArticleen_US

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