Hyperbaric oxygen treatment augments the efficacy of a losartan regime in an experimental nephrotic syndrome model

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dc.contributor.authorYilmaz M.I.
dc.contributor.authorKorkmaz A.
dc.contributor.authorKaya A.
dc.contributor.authorSonmez A.
dc.contributor.authorCaglar K.
dc.contributor.authorTopal T.
dc.contributor.authorEyileten T.
dc.contributor.authorYenicesu M.
dc.contributor.authorAcikel C.
dc.contributor.authorOter S.
dc.contributor.authorYaman H.
dc.contributor.authorAktug H.
dc.contributor.authorOguz Y.
dc.contributor.authorVural A.
dc.contributor.authorIkizler T.A.
dc.date.accessioned2019-10-27T00:09:26Z
dc.date.available2019-10-27T00:09:26Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: Proteinuria is associated with oxidant stress and inflammation. Hyperbaric oxygen (HBO) treatment has anti-inflammatory and anti-oxidant effects. The aim of the study was to investigate the benefits of HBO treatment on an experimental nephrotic syndrome model. Methods: 50 male Sprague-Dawley rats weighing 255 ± 39 g were housed. Forty rats were injected 6 mg/kg adriamycin into tail veins under anesthesia to induce nephrosis, while 10 rats were spared as sham control. After the stabilization of proteinuria at the sixth week, the rats were treated for 6 weeks by losartan (n = 10, 30 mg/kg/day), HBO (n = 10, 2.8 atmosphere absolute, 90 min/day), HBO + losartan (n = 10) and vehicle (n = 10). Protein carbonyl (PCO), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were analyzed from tissue specimens. Biochemical markers were studied from venous samples and 24-hour urine was collected for proteinuria. The surviving animals at 12 weeks (vehicle group (n = 6), HBO (n = 6), losartan (n = 8), HBO + losartan (n = 10) were sacrificed. Glomerular sclerosis, tubulointerstitial and blood vessel changes were determined by semiquantitative scoring. Results: The PCO levels increased (p < 0.001), and the GPx and SOD levels decreased (p < 0.001 for both) in the nephrotic rats. In losartan and HBO groups GPx levels increased (p = 0.001, p = 0.002 respectively), but PCO and SOD levels did not change. The combination of HBO with losartan significantly increased the GPx and SOD levels (p = 0.001 for both) and decreased PCO levels (p = 0.005). HBO but not losartan significantly reduced proteinuria (p < 0.001). The combination of HBO and losartan reduced proteinuria better than the single losartan regime (p < 0.001). The effect of the combination was also noticed on the histological examination of the kidneys. The activities, appetites, weight gains, and improvement of edema were better in the HBO combined with losartan regime. Conclusions: These results indicate that the addition of HBO therapy to a conventional regime, angiotensin receptor blockers, has significant benefits in the management of proteinuria. Future clinical studies are needed to elucidate the role of HBO and other antioxidant strategies in the treatment of proteinuria. Copyright © 2006 S. Karger AG.en_US
dc.identifier.doi10.1159/000093260en_US
dc.identifier.endpagee22en_US
dc.identifier.issn1660-2129
dc.identifier.issue1en_US
dc.identifier.pmid16699289en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpagee15en_US
dc.identifier.urihttps://doi.org/10.1159/000093260
dc.identifier.urihttps://hdl.handle.net/11454/21677
dc.identifier.volume104en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofNephron - Experimental Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperbaric oxygenen_US
dc.subjectLosartanen_US
dc.subjectProteinuriaen_US
dc.titleHyperbaric oxygen treatment augments the efficacy of a losartan regime in an experimental nephrotic syndrome modelen_US
dc.typeArticleen_US

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