Association of heartburn during pregnancy with the risk of gastroesophageal reflux disease

Basit Öğe Kaydı
dc.contributor.authorBor, Serhat
dc.contributor.authorKitapcioglu, Gul
dc.contributor.authorDettmar, Peter
dc.contributor.authorBaxter, Tim
dc.date.accessioned2019-10-27T19:32:38Z
dc.date.available2019-10-27T19:32:38Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground & Aims: Heartburn and gastroesophageal reflux disease (GERD) during pregnancy are accepted as an innocent condition. The effect of heartburn during pregnancy on the initiation or progress of GERD is not known. We aimed to determine the predisposition effect of heartburn during pregnancy for presenting with GERD in the future. Methods: A validated reflux questionnaire was applied to 1180 randomly selected women aged between 18-49 years who had given birth to at least one delivery. Frequent symptoms were defined as a major symptom (heartburn and/or regurgitation) occurring at least once a week or more. Occasional symptoms were defined as an episode of one of the major symptoms occurring less than once a week within the past 12 months. Results: The mean live delivery rate was 2 +/- 1 (range, 1-10). The prevalence of GERD was 7.4%. Whereas the prevalence of GERD for women with a history of just 1 delivery was 1.5%, more than 2 deliveries were accompanied with risk of 15.1% (P <.001). In the group with no heartburn during pregnancy only 5.5% had GERD (P <.00001). If there was heartburn during any of the pregnancies, the risk was 17.7%; and more than 2 pregnancies with a history of heartburn accompanied 36.1% risk of having GERD. Logistic regression analysis showed that the risk is independent from obesity and age. Conclusions: The risk of GERD is increased by the presence of heartburn during pregnancy. This association is independent of obesity and age. Heartburn during pregnancy might not be accepted as an innocent and temporary condition.en_US
dc.identifier.doi10.1016/j.cgh.2007.05.003en_US
dc.identifier.endpage1039en_US
dc.identifier.issn1542-3565
dc.identifier.issue9en_US
dc.identifier.pmid17644491en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2007.05.003
dc.identifier.urihttps://hdl.handle.net/11454/39319
dc.identifier.volume5en_US
dc.identifier.wosWOS:000249642400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofClinical Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation of heartburn during pregnancy with the risk of gastroesophageal reflux diseaseen_US
dc.typeArticleen_US

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