Investigation of Phlebotominae (Diptera: Psychodidae) Fauna, Seasonal Dynamics, and Natural Leishmania spp. Infection in Mug?la, Southwest of Turkey

Basit Öğe Kaydı
dc.contributor.authorPekagirbas, Metin
dc.contributor.authorKarakus, Mehmet
dc.contributor.authorKasap, Ozge Erisoz
dc.contributor.authorDemir, Samiye
dc.contributor.authorNalcaci, Muhammed
dc.contributor.authorToz, Seray
dc.contributor.authorOzbel, Yusuf
dc.date.accessioned2021-05-03T20:21:29Z
dc.date.available2021-05-03T20:21:29Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractDue to its geographical location, Mug?la province is one of the most frequently used places by refugees. Although leishmaniasis have been previously reported in this region, there is a lack of information on the etiological agent and possible vectors. The main objectives of this study were; i) to investigate the sand fly fauna, ii) to reveal the natural Leishmania spp. infection in wild caught sand flies using molecular tools, and iii) to determine the annual seasonal dynamics of the sand flies in Mug?la region. Totally, 2093 specimens belonging to 15 species [12 Phlebotomus, three Sergentomyia; 51 unidentified] were collected during the one-year (June 2016-June 2017) period. of the collected sand flies, 1928 (92.12%) were caught by the Centers for Disease Control (CDC) light traps, while 165 (7.88%) of them were caught by sticky traps. Phlebotomus major sensu lato (s.l.), the potential vector of visceral leishmaniasis (VL) and canine leishmaniasis (CanL) in the Mediterranean and Aegean region, was detected in all sampling locations and found as the dominant taxon (n=1035; 49.45%) of the study area and followed by Phlebotomus tobbi (n=371; 17.72%). During the sampling period, sand fly activity was started in March and peaked in August. Sand fly population size reduced dramatically between mid-September and early October. The number of collected specimens was peaked in August, while there is only one sample collected both in November and March. The majority of the sand flies (78.66%) were collected at an altitude range of 200-400 m. Seventy-two monospecific pools were screened for the presence of Leishmania DNA by real time ITS1 PCR and 24 (nine P. major s.l., eight P. tobbi, two P. papatasi, two S. minuta, one P. alexandri, one P. similis, and one Phlebotomus (Transphlebotomus spp.) of them (33.8%) were found positive (L. infantum, L. tropica, and L. major). To the best of our knowledge, the presence of fifteen sand fly species and their distribution, seasonal dynamics, molecular detection of Leishmania parasites in Mug?la province was reported for the first time. The presence of vector species in the study area, appropriate temperature and humidity conditions, long sand fly activity season, and presence of Leishmania parasite suggests that there is a serious risk in the transmission of leishmaniasis in Mug?la.en_US
dc.description.sponsorshipTeaching Staff Training ProgramHigher Education Council (OYP-YOK); Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S999]en_US
dc.description.sponsorshipThis work was supported by the Teaching Staff Training ProgramHigher Education Council (OYP-YOK) and The Scientific and Technological Research Council of Turkey (TUB.ITAK) Project No: 114S999.en_US
dc.identifier.doi10.1016/j.actatropica.2021.105827en_US
dc.identifier.issn0001-706X
dc.identifier.issn1873-6254
dc.identifier.pmid33428877en_US
dc.identifier.scopus2-s2.0-85099438191en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.actatropica.2021.105827
dc.identifier.urihttps://hdl.handle.net/11454/69340
dc.identifier.volume216en_US
dc.identifier.wosWOS:000632459000009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofActa Tropicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSeasonal dynamicsen_US
dc.subjectPhlebotomusen_US
dc.subjectLeishmaniaen_US
dc.subjectCOX1en_US
dc.subjectTurkeyen_US
dc.titleInvestigation of Phlebotominae (Diptera: Psychodidae) Fauna, Seasonal Dynamics, and Natural Leishmania spp. Infection in Mug?la, Southwest of Turkeyen_US
dc.typeArticleen_US

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