Intense myelofibrosis in a child: Unusual result of EBV-associated hemophagocytic lymphohistiocytosis

Basit Öğe Kaydı
dc.contributor.authorKarapinar B.
dc.contributor.authorYilmaz D.
dc.contributor.authorAydinok Y.
dc.contributor.authorTürkoglu E.
dc.contributor.authorHekimgil M.
dc.contributor.authorKavakli K.
dc.date.accessioned2019-10-26T23:59:20Z
dc.date.available2019-10-26T23:59:20Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractA previously healthy 12-year-old girl was admitted to the intensive care unit with severe pulmonary bleeding. Her history revealed that she had suffered from high fever, fatigue, sore throat, myalgia and generalized rash for two weeks. Physical examination revealed hepatosplenomegaly. Laboratory investigation showed pancytopenia associated with unusual high levels of serum ferritin, triglyceride and lactate dehydrogenase (LDH) and low fibrinogen levels. Apparent hemophagocytosis was seen in bone marrow aspiration. Bone marrow biopsy revealed myelofibrosis, and confirmed hemophagocytosis. IgM for Epstein-Barr virus (EBV) viral capsid antigen was found to be positive. She received chemotherapy for 10 days according to hemophagocytic lymphohistiocytosis (HLH)-2004 treatment protocol, since the symptoms persisted despite supportive therapy and intravenous immunoglobulin (IVIG) administration. However, the clinical status and laboratory findings did not respond to treatment and she died from severe pulmonary bleeding associated with prolonged ventilator support and sepsis. Intense myelofibrosis, which is reported rarely, particularly in patients with EBV-related HLH, contributed to this fatal prognosis. © Turkish Society of Hematology.en_US
dc.identifier.endpage35en_US
dc.identifier.issn1300-7777
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://hdl.handle.net/11454/21375
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChilden_US
dc.subjectEBVen_US
dc.subjectHemophagocytic lymphohistiocytosisen_US
dc.subjectMyelofibrosisen_US
dc.subjectPancytopeniaen_US
dc.titleIntense myelofibrosis in a child: Unusual result of EBV-associated hemophagocytic lymphohistiocytosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu