Investigation of human herpesvirus 6 infections in kidney and bone marrow/stem cell transplant recipients [Böbrek ve kemi·k i·li·gi·/kök hücre alicilarinda i·nsan herpesvi·rus 6 enfeksi·yonunun araştirilmasi]

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dc.contributor.authorÖzkalay N.
dc.contributor.authorÖzacar T.
dc.contributor.authorAşçi G.
dc.contributor.authorTöz H.
dc.contributor.authorKansoy S.
dc.date.accessioned2019-10-27T00:23:20Z
dc.date.available2019-10-27T00:23:20Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, active human herpesvirus (HHV)-6 infection were investigated in 39 renal and 9 bone marrow/stem cell transplant recipients. For this purpose, the presence of HHV-6 DNA in patients sera have been searched by nested polymerase chain reaction (nPCR). In addition, HHV-6 IgM and IgG antibodies were performed by micro-enzyme immunoassay (EIA) to detect seronegative patients before transplantation and IgM response in active or primary HHV-6 infection. Active infection with HHV-6 DNA positivity was detected in 5.3% of renal and 22.2% of bone marrow/stem cell transplant recipients. Active HHV-6 infection was found to be related with asemptomatic reactivation, graft disfunction and cytomegalovirus disease in renal transplant recipients, and, fever and graft versus host disease in bone marrow/stem cell transplant recipients. It has been concluded that, the investigation of HHV-6 DNA by nPCR in the transplant sera, was a practical and useful method for the laboratories, in order to diagnose active HHV-6 infection, while HHV-6 IgG antibody detection was also useful for the differentional diagnosis of primary infection or reactivation/reinfection, but HHV-6 IgM antibodies has low value to detect active HHV-6 infection.en_US
dc.identifier.endpage186en_US
dc.identifier.issn0374-9096
dc.identifier.issue02.Maren_US
dc.identifier.pmid14593901en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://hdl.handle.net/11454/22789
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone marrow and stem cell transplantationen_US
dc.subjectHuman herpesvirus-6en_US
dc.subjectKidney transplantationen_US
dc.titleInvestigation of human herpesvirus 6 infections in kidney and bone marrow/stem cell transplant recipients [Böbrek ve kemi·k i·li·gi·/kök hücre alicilarinda i·nsan herpesvi·rus 6 enfeksi·yonunun araştirilmasi]en_US
dc.typeArticleen_US

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