Successful desensitization of a case with desferrioxamine hypersensitivity

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dc.contributor.authorGülen F.
dc.contributor.authorDemir E.
dc.contributor.authorTanaç R.
dc.contributor.authorAydinok Y.
dc.contributor.authorGulen H.
dc.contributor.authorYenigün A.
dc.contributor.authorCan D.
dc.date.accessioned2019-10-27T00:01:40Z
dc.date.available2019-10-27T00:01:40Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractThalassaemia major is a severe chronic hemolytic disease, resulted with iron overload mainly due to regular blood transfusions. Iron overload may lead to serious organ toxicity and even fatal complications, if no iron excretion is achieved by a chelating agent. First introduced in 1976 as s.c. treatment for thalassaemia major, desferrioxamine (DFO) has substantially improved the life expectancy in the disease. While DFO can cause local allergic reactions including redness, itching, pain and lumps, on rare occasion anaphylactic reactions can occur. The mechanism of anaphylaxis like reactions is not well understood. In this case report, we presented a 10 years-old girl with thalassaemia major who had to stop DFO therapy after appearing of systemic allergic reactions with hypotension, tachycardia, pruritus and urticaria against this drug. Serum IgE level was normal, specific IgE and skin prick tests were negative. Intradermal test was resulted with positive reaction to DFO. The patient was hospitalized and desensitization protocol was initiated with rapid s.c. infusions per 15 min. The protocol was stopped at the 17th cycle because of local reaction reappeared. After that, DFO was further diluted and was restarted with lower dosage and longer infusion period. Then, DFO dosage was increased and the dilutions and infusion times were decreased gradually. By this desensitization programme, the patient would continue to use DFO chelation safely for 10 months.en_US
dc.identifier.endpage574en_US
dc.identifier.issn0026-4946
dc.identifier.issue6en_US
dc.identifier.pmid17093379en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage571en_US
dc.identifier.urihttps://hdl.handle.net/11454/21563
dc.identifier.volume58en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofMinerva Pediatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergyen_US
dc.subjectDesferrioxamineen_US
dc.subjectThalassemiaen_US
dc.titleSuccessful desensitization of a case with desferrioxamine hypersensitivityen_US
dc.typeArticleen_US

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