Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria

Basit Öğe Kaydı
dc.contributor.authorBaris, Necla
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorSezer, Ebru
dc.contributor.authorSaygili, Fuesun
dc.contributor.authorOzgonul, A. Mert
dc.contributor.authorTurgan, Nevbahar
dc.contributor.authorErsoz, Biltan
dc.date.accessioned2019-10-27T21:19:00Z
dc.date.available2019-10-27T21:19:00Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractLow-grade inflammation is closely involved in the pathogenesis of type 2 diabetes and associated micro- and macrovascular complications. The nitric oxide (NO) precursor l-arginine, is relevant to diverse pathological conditions including type 2 diabetes and its complications. High sensitive-CRP (hs-CRP), neopterin and arginine levels were measured in 46 normoalbuminuric, 45 microalbuminuric type 2 diabetics and in 32 healthy controls in order to assess the relationship between markers of inflammation and l-arginine. Hs-CRP concentrations were higher in microalbuminuric diabetic patients compared to normoalbuminuric patients and controls. Diabetics had higher serum and urine neopterin levels than controls. Urine neopterin and l-arginine levels differed significantly among diabetic patients with and without microalbuminuria. There were significant positive correlations between hs-CRP and BMI in healthy controls and diabetics with and without microalbuminuria. In microalbuminuric diabetics, hs-CRP correlated with microalbuminuria (MAU). Significant predictors for the development of microalbuminuria were higher postprandial glucose levels, lower creatinine clearance and lower serum l-arginine levels. Assessment of early markers of inflammation and endothelial function, such as neopterin and NO precursor l-arginine, may help to predict incipient nephropathy more accurately in type 2 diabetic patients.en_US
dc.identifier.doi10.1007/s00592-008-0089-9en_US
dc.identifier.endpage316en_US
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.issue4en_US
dc.identifier.pmid19183843en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.1007/s00592-008-0089-9
dc.identifier.urihttps://hdl.handle.net/11454/44078
dc.identifier.volume46en_US
dc.identifier.wosWOS:000271479900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofActa Diabetologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicroalbuminuriaen_US
dc.subjectNeopterinen_US
dc.subjectL-Arginineen_US
dc.subjectHs-CRPen_US
dc.subjectEndothelial functionen_US
dc.subjectCardiovascular risken_US
dc.titleAlterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuriaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu