Cholecalciferol (vitamin D 3) improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndrome

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dc.contributor.authorErbas, Oytun
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorAksoy, Durdane
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorSagcan, Mustafa
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T22:15:01Z
dc.date.available2019-10-27T22:15:01Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: The aim of this study was to examine the effects of cholecalciferol on systemic inflammation and memory in the setting of fatty liver disease in rats. Materials and methods: To induce the development of fatty liver disease, the rats were fed a 35% fructose solution over 8 weeks. Group I (n = 6) was designated as the control group and fed with standard rat chow. Group II (n = 6) was provided with, standard rat chow, and 03 mu g/kg/day of oral cholecalciferol over a duration of 2 weeks. In addition to standard rat chow, group III (n = 6) and group IV (n = 6) were given 4 mL of the 35% fructose solution per day via oral gavage for 8 weeks. However, group IV was also given 03 mu g/kg/day of oral cholecalciferol over 2 weeks. After the treatment period, passive avoidance tasks were performed by all groups. The liver and brain were harvested for subsequent biochemical and histopathologic analyses. Key findings: The development of fatty liver extends the memory latency period of passively avoiding tasks after I trial. Moreover, there were increases in brain TNF-alpha and plasma MDA levels according to two-way analysis of variance. Cholecalciferol supplementation decreased the latency period of passively avoiding tasks in rats with hepatosteatosis, and also significantly reduced brain TNF-alpha and plasma MDA levels. Significance: Fatty liver may contribute to the development of systemic inflammation, which affects cognition and causes deficits in memory; however, the anti-inflammatory and antioxidant properties of vitamin D may improve the cognitive function of rats with hepatosteatosis. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.lfs.2014.03.035en_US
dc.identifier.endpage72en_US
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.issue2en_US
dc.identifier.pmid24727236en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2014.03.035
dc.identifier.urihttps://hdl.handle.net/11454/50106
dc.identifier.volume103en_US
dc.identifier.wosWOS:000336356600002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFatty liveren_US
dc.subjectMemory functionsen_US
dc.subjectInflammationen_US
dc.subjectCholecalciferolen_US
dc.titleCholecalciferol (vitamin D 3) improves cognitive dysfunction and reduces inflammation in a rat fatty liver model of metabolic syndromeen_US
dc.typeArticleen_US

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