Thymic output changes in children with clinical findings signaling a probable primary immunodeficiency

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dc.contributor.authorKaraca, Neslihan
dc.contributor.authorAzarsız, Elif
dc.contributor.authorAkarcan, Sanem Eren
dc.contributor.authorAksu, Güzide
dc.contributor.authorKütükçüler, Necil
dc.date.accessioned2020-12-01T12:37:23Z
dc.date.available2020-12-01T12:37:23Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractThymic maturation evaluation is inevitable for patients with clinical and laboratory findings for a primary immunodeficiency, as the T cellimmunodeficiencies are the most severe type. in this study, we aimed to show the usage of T cell surface molecule “CD31” for the evaluation of thymic output in patients (n: 66) with a large spectrum of findings signing a probable primary immunodeficiency. Besides the classical clinical and laboratory approach for these patients, T cell subpopulations as naive, memory, recent thymic emigrant cells were also investigated. the humoral immunodeficiency (34.8%), combined immunodeficiency (34.8%) and cardiopathy (7.6%) were the most frequent diagnosis groups. CD4+CD45RA+ naive T-cells percentages (p: 0.011) and absolute counts (p: 0.004) and absolute CD4+CD45RA+CD31+ RTE (recent thymic emigrant) cell counts (p: 0.007) were significantly lower in combined immunodeficiency group. Naive T-cells (p: 0.037) and RTE cells (p: 0.032) were also lower in patients who had cardiac surgery in the past. in conclusion, flow cytometric CD31+thymic naive RTE cell evaluation may provide rapid clinical information especially on T-cell immune dysfunction and CD4+CD45RA+CD31+ RTE cells may be used as an alternative to TRECs in the diagnosis of combined immunodeficiencies.en_US
dc.identifier.doi10.24953/turkjped.2019.06.010
dc.identifier.endpage894en_US
dc.identifier.issn0041-4301
dc.identifier.issue6en_US
dc.identifier.startpage885en_US
dc.identifier.urihttps://doi.org/10.24953/turkjped.2019.06.010
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TXpVek5EUXdNQT09
dc.identifier.urihttps://hdl.handle.net/11454/67168
dc.identifier.volume61en_US
dc.identifier.wosWOS:000518859600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject0-Belirleneceken_US
dc.titleThymic output changes in children with clinical findings signaling a probable primary immunodeficiencyen_US
dc.typeArticleen_US

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