PURE vs. mixed clear cell ovarian carcinomas: Is there any impact on survival?

Basit Öğe Kaydı
dc.authoridSerin, Gürdeniz/0000-0003-4204-0601
dc.contributor.authorGuzel, Duygu
dc.contributor.authorTerek, Cosan
dc.contributor.authorBesler, Aysegul
dc.contributor.authorSerin, Gurdeniz
dc.contributor.authorOnal, Zueleyha
dc.contributor.authorAkman, Levent
dc.contributor.authorGoker, Erdem
dc.date.accessioned2024-08-31T07:47:46Z
dc.date.available2024-08-31T07:47:46Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Our primary aim in this study is to define the clinical characteristics of patients with clear-cell ovarian carcinoma and evaluate the prognostic factors affecting survival. Study design: Records of 85 patients, operated between 2000 and 2018, for an adnexal mass and whose final pathology reported clear cell ovarian carcinoma were reviewed. The study considered demographic data, clinical characteristics of the patients, as well as pure and mixed-type clear cell histology. The patients' follow-up time, disease-free and overall survival recorded. The primary outcomes were disease-free survival (DFS) and overall survival (OS). Results: The median age of the patients at diagnosis was 52. In 64.7 % of the cases, clear cell histology was pure, while the others (35.3 %) were mixed. Patients with ovarian endometriosis constituted 27.1 % of the whole population. The median OS for the entire population was 92 months (95 %CI:72-124). On univariate and multivariate analyses, advanced age was found to have a significant independent impact on OS and DFS (p < 0.05) and, was associated with a worse prognosis. Also, the multivariate analyses showed that the presence of endometriosis has a significant independent impact on OS (p < 0.05). When examining the relationship between the histological origin (mixed vs. pure) and 5-year survival, the mixed type showed longer OS and DFS rates (76.8 % vs. 69.8 %, 61.5 % vs. 53.8 %), the difference was not statistically significant (p > 0.05). Conclusion: This retrospective study showed that although mixed type histological origin was associated with higher OS and DFS rates compared to pure type in patients with CCOC, the difference was not statistically significant. Advanced age and the presence of endometriosis was found to have a significant independent effect on OS and DFS and was associated with a worse prognosis. Overall, this study provides useful insights into the clinical characteristics of patients with CCOC and identifies important prognostic factors affecting survival.en_US
dc.identifier.doi10.1016/j.ejogrb.2024.03.021
dc.identifier.endpage326en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid38518487en_US
dc.identifier.scopus2-s2.0-85188582389en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2024.03.021
dc.identifier.urihttps://hdl.handle.net/11454/104524
dc.identifier.volume296en_US
dc.identifier.wosWOS:001216084000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectClear Cell Ovarian Carcinomaen_US
dc.subjectEndometriosisen_US
dc.subjectLymphadenectomyen_US
dc.subjectChemotherapyen_US
dc.subjectHistological Originen_US
dc.titlePURE vs. mixed clear cell ovarian carcinomas: Is there any impact on survival?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu