Acute Lithium Neurotoxicity: Clinical and Electrophysiological Evaluation of Four Cases
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal Neurological Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Lithium is one of the first choice agents for long-term prophylaxis and the treatment of acute episodes of bipolar disorders. Because of its narrow therapeutic range and the common undesirable side effects, using lower lithium dosages with lower lithium serum levels are preferred treatment regimen especially for maintenance treatment. Concomitant drug using (especially neuroleptics), underlying infections and metabolic causes; such as dehydration and renal insufficiency take place in factors facilitating the development of toxicity. Lithium intoxication is distinguished in three different patterns as "acute", "chronic" and "toxicity during chronic use". Although patients with lithium poisoning may present with a variety of clinical manifestations, neurological symptoms appeared to dominate with a certain risk of persistency. In this report, four cases of lithium intoxication with neurological complications were presented with clinical and electrophysiological findings and lithium neurotoxicity was reviewed with recent literature.
Açıklama
Anahtar Kelimeler
Lithium, toxicity, neurotoxicity, encephalopathy, epilepsy
Kaynak
Journal of Neurological Sciences-Turkish
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
2
