Extraction and characterization of novel multifunctional peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activities

Basit Öğe Kaydı
dc.contributor.authorKula, Elif
dc.contributor.authorKocazorbaz, Ebru Kocadag
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorAlpat, Senol
dc.contributor.authorZihnioglu, Figen
dc.date.accessioned2020-12-01T12:01:30Z
dc.date.available2020-12-01T12:01:30Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractMarine organisms represent a great source of natural bioactive molecules, from which bioactive peptides are of great importance in biomedicine application in many diseases such as diabetes and its related complications. in this study, greater weever (Trachinus Draco) myofibrillar proteins were sequentially hydrolyzed and the different RP-HPLC purified fractions were tested for potential inhibitory activities of ACE and DPP4, in addition to metal chelation and antioxidant activities. Four fractions were found to have high levels of activity (with two peptides being multifunctional) and were subsequently sequenced using the de novo sequencing method. the results indicate that the peptides are novel and highly effective for each related activity compared to reference molecules. the current findings suggest these multifunctional peptides as promising therapeutics against oxidative stress, hypertension, and diabetes. Practical applications We have described the finding of two multifunctional bioactive peptides from Trachinus Draco (greater weever) myofibrillar proteins having two or more activities. They have ACE inhibitory, DPP4 inhibitory, antioxidant, and metal chelation activities. These new peptides could be used for future biomedicine applications as a stand-alone treatment, in combination with other molecules, or as a supplement. Furthermore, after identification of their sequence in our work, it would have a great potential to be artificially synthesized. the field of food supplements could be explored further.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [Short Term R and D Funding Program (1002), 215Z486] Funding Source: Medlineen_US
dc.identifier.doi10.1111/jfbc.13179en_US
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue5en_US
dc.identifier.pmid32153045en_US
dc.identifier.scopus2-s2.0-85081207052en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jfbc.13179
dc.identifier.urihttps://hdl.handle.net/11454/62436
dc.identifier.volume44en_US
dc.identifier.wosWOS:000533989300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectACE inhibitionen_US
dc.subjectantioxidant activityen_US
dc.subjectDPP4 inhibitionen_US
dc.subjectmetal chelating activityen_US
dc.subjectmultifunctional peptidesen_US
dc.subjectTrachinus Dracoen_US
dc.titleExtraction and characterization of novel multifunctional peptides from Trachinus Draco (greater weever) myofibrillar proteins with ACE/DPP4 inhibitory, antioxidant, and metal chelating activitiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu