Expression of interleukin-8 and monocyte chemotactic protein 1 in women with endometriosis

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dc.contributor.authorUlukus, Murat
dc.contributor.authorUlukus, E. Cagnur
dc.contributor.authorGoker, Ege N. Tavinergen
dc.contributor.authorTavmergen, Erol
dc.contributor.authorZheng, Wenxin
dc.contributor.authorArici, Aydin
dc.date.accessioned2019-10-27T20:19:09Z
dc.date.available2019-10-27T20:19:09Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To investigate the expression and localization of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in women with and without endometriosis. Design: Comparative immunohistochemical study. Setting: Academic medical center. Patient(s): Ectopic (n = 24) and homologous eutopic endometrium (n = 24) from women with endometriosis and endometrium from women without endometriosis (n = 27) were used for immunohistochemical analysis of IL-8 and MCP-1. Intervention(s): Tissue sections were immunostained with antihuman IL-8 and MCP-1 antibodies. Main Outcome Measure(s): Microscopic evaluation to assess the presence and localization of IL-8 and MCP-1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with endometriosis and comparison with normal endometrium. Result(s): In normal endometrium. secretory phase samples expressed higher levels of epithelial IL-8 than in proliferative phase samples. Epithelial MCP-1 expression was similar in both proliferative and secretory phases. Proliferative phase samples showed higher epithelial IL-8 and MCP-1 expressions in eutopic endometrium of women with endometriosis compared with that of normal women. Immunoreactivities of both chemokines were significantly increased in the epithelial cells of ectopic endometrial tissues compared with those of normal endometrium. Conclusion(s): These findings Suggest that IL-8 and MCP-1 may be involved in the pathogenesis of endometriosis. (Fertil Steril (R) 2009;91:687-93. (C) 2009 by American Society for Reproductive Medicine.)en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Institution (TUBITAK) training awardTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipSupported by a Turkish Scientific and Technical Research Institution (TUBITAK) training award to Murat Ulukus.en_US
dc.identifier.doi10.1016/j.fertnstert.2007.12.067en_US
dc.identifier.endpage693en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3en_US
dc.identifier.pmid18314120en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage687en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2007.12.067
dc.identifier.urihttps://hdl.handle.net/11454/41340
dc.identifier.volume91en_US
dc.identifier.wosWOS:000264143500007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriosisen_US
dc.subjectendometriumen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinterleukin-8en_US
dc.subjectmonocyte chemotactic protein 1en_US
dc.titleExpression of interleukin-8 and monocyte chemotactic protein 1 in women with endometriosisen_US
dc.typeArticleen_US

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