Assessment of in vitro Cytotoxic, iNOS, Antioxidant and Photodynamic Antimicrobial Activities of Water-soluble Sulfonated Phthalocyanines

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dc.authoridGüzel, Emre/0000-0002-1142-3936
dc.authoridAKIN, mustafa/0000-0003-4268-6891
dc.authorscopusid55711538200
dc.authorscopusid8724147000
dc.authorscopusid55579369300
dc.authorscopusid57224629270
dc.authorscopusid35100694300
dc.authorscopusid7005150117
dc.authorwosidGüzel, Emre/H-2692-2018
dc.authorwosidAKIN, Mustafa/F-3682-2016
dc.contributor.authorAkin, Mustafa
dc.contributor.authorSaki, Neslihan
dc.contributor.authorGuzel, Emre
dc.contributor.authorOrman, Batuhan
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorKocak, Makbule B.
dc.date.accessioned2023-01-12T20:02:28Z
dc.date.available2023-01-12T20:02:28Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractIn recent years, much effort has been devoted to the development of effective anticancer agents. In this manner, the utilization of water-soluble sulfonated phthalocyanines is crucial for many cancer cell lines. In this study, phthalonitrile and metallophthalocyanine compounds linked by benzenesulfonic acid groups have been prepared. Antimicrobial behaviors of those compounds were investigated by performing disk diffusion and photodynamic assays on gram-positive and negative bacteria. Indium phthalocyanine (InClPc) (3) showed inhibition activity against B. cereus, B. subtilis and S. aureus with disk diffusion assay. Also, gallium and indium phthalocyanines (2 and 3) exhibited inhibitory activity on both gram-positive and -negative microorganisms after light activation. Increasing the inhibitor concentration and light exposure time increased the inhibition activity for both molecules. GaClPc (2) demonstrated the maximum reducing power capacity among studied compounds, and CoPc (4) showed even better DPPH radical scavenging ability than the standard molecule Trolox at 2000 mu g mL(-1) concentration. The dose-dependent effect of compounds on cytotoxicity was studied against cancer cells PANC-1, MDA-MB-231, HepG2, A549, HeLa, CaCo-2 and non-tumorigenic cells HEK-293. All compounds showed no significant cytotoxic effect on any cell line up to the highest treated concentration at 50 mu g mL(-1). However, all phthalocyanines had significant nitric oxide inhibition activity, and only in copper phthalocyanine (CuPc) (5), the MTT IC50 value was reached on LPS-activated RAW 264.7 macrophage cells. The lowest inducible nitric oxide synthase (iNOS) IC50 values were defined as 6 +/- 1 mu g mL(-1) and 7 +/- 0.5 mu g mL(-1) for CuPc (5) and InClPc (3), respectively.en_US
dc.identifier.doi10.1111/php.13558
dc.identifier.endpage915en_US
dc.identifier.issn0031-8655
dc.identifier.issn1751-1097
dc.identifier.issue4en_US
dc.identifier.pmid34748237en_US
dc.identifier.scopus2-s2.0-85119620816en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage907en_US
dc.identifier.urihttps://doi.org/10.1111/php.13558
dc.identifier.urihttps://hdl.handle.net/11454/77592
dc.identifier.volume98en_US
dc.identifier.wosWOS:000721020700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPhotochemistry and Photobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrowave-Assisted Synthesisen_US
dc.subjectSinglet Oxygen Generationen_US
dc.subjectAluminum Phthalocyanineen_US
dc.subjectMetal-Freeen_US
dc.subjectPhotosensitizersen_US
dc.subjectTherapyen_US
dc.subjectAggregationen_US
dc.subjectDoxorubicinen_US
dc.subjectAureusen_US
dc.subjectZincen_US
dc.titleAssessment of in vitro Cytotoxic, iNOS, Antioxidant and Photodynamic Antimicrobial Activities of Water-soluble Sulfonated Phthalocyaninesen_US
dc.typeArticleen_US

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