Mannose-Binding Lectin Gene Polymorphism and Chronic Hepatitis B Infection in Children

Basit Öğe Kaydı
dc.contributor.authorErdemir, Gulin
dc.contributor.authorOzkan, Tanju B.
dc.contributor.authorOzgur, Taner
dc.contributor.authorBudak, Ferah
dc.contributor.authorKilic, Sara S.
dc.contributor.authorOnay, Huseyin
dc.date.accessioned2019-10-27T19:54:32Z
dc.date.available2019-10-27T19:54:32Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/Aims: Mannose-binding lectin (MBL) is a member of innate immune system that activates complement system through lectin pathway. MBL deficiency is associated with susceptibility to infectious diseases. In this study, the relation between MBL gene polymorphism and chronic hepatitis B infection in children is evaluated. Patients and Methods: The study included 67 children with chronic hepatitis B and 99 healthy controls. The hepatitis B patients were divided into immuntolerant, chronic inactive, and treatment groups according to their laboratory findings. MBL gene codon 52, 54, and 57 polymorphisms were studied with polymerase chain reaction in all patients and controls. The associations of MBL gene polymorphism with clinical, laboratory, and histopathologic findings were evaluated. Results: Homozygous codon 54 polymorphism of MBL was found significantly higher in chronic hepatitis B patients than controls. Rate of the polymorphism was similar in all groups and, responsive and nonresponsive patients in the treatment group. Conclusions: The hepatitis B patients who are homozygous for codon 54 of MBL are prone to develop chronic infection. Longitudinal studies with larger groups are needed.en_US
dc.description.sponsorshipUludag University Scientific Research ProjectsUludag University [UAP (T)-2009/32]en_US
dc.description.sponsorshipUludag University Scientific Research Projects, grant UAP (T)-2009/32.en_US
dc.identifier.doi10.4103/1319-3767.153825en_US
dc.identifier.endpage89en_US
dc.identifier.issn1319-3767
dc.identifier.issn1998-4049
dc.identifier.issue2en_US
dc.identifier.pmid25843194en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.4103/1319-3767.153825
dc.identifier.urihttps://hdl.handle.net/11454/40515
dc.identifier.volume21en_US
dc.identifier.wosWOS:000352013700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofSaudi Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildhooden_US
dc.subjectchronic hepatitis Ben_US
dc.subjectinnate immunityen_US
dc.subjectmannose-binding lectinen_US
dc.titleMannose-Binding Lectin Gene Polymorphism and Chronic Hepatitis B Infection in Childrenen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu