Prophylactic use of ondansetron for emesis after craniofacial operations in children

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dc.contributor.authorGurler, T
dc.contributor.authorCelik, N
dc.contributor.authorTotan, S
dc.contributor.authorSongur, E
dc.contributor.authorSakarya, M
dc.date.accessioned2019-10-27T11:51:10Z
dc.date.available2019-10-27T11:51:10Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractChildren who undergo craniofacial operations are especially at risk of postoperative nausea and vomiting. These operations are more complex than the craniotomies for resective procedures. Postoperative vomiting is a common occurrence that can delay recovery and result in cerebrospinal fluid leak acid fistula formation in these patients. Ondansetron, a selective serotonergic antagonist, is effective in reducing postoperative nausea and vomiting in several high-risk populations. In a randomized, double-blind, placebo-controlled study, the authors compared the prophylactic use of intravenous ondansetron 0.15 mg/kg with induction of anesthesia versus a placebo of normal saline 0.3 ml/kg with induction. A second dose was given 8 hours after the first dose. After surgery, episodes of vomiting were recorded separately in 0 to 2 hours, 2 to 6 hours, 6 to 12 hours, 12 to 24 hours, and 24 to 48 hours. Postoperative vomiting is significantly reduced in the ondansetron group compared with the placebo group (P = 0.000258). Ondansetron is effective in the prevention of postoperative vomiting in the pediatric population undergoing craniofacial operations.en_US
dc.identifier.endpage48en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue1en_US
dc.identifier.pmid10388426en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/11454/34496
dc.identifier.volume10en_US
dc.identifier.wosWOS:000077966200010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpostoperative nausea and vomitingen_US
dc.subjectcraniofacial surgeryen_US
dc.titleProphylactic use of ondansetron for emesis after craniofacial operations in childrenen_US
dc.typeArticleen_US

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