The Effect of L-Carnitine on Platelet Activating Factor Concentration in the Immature Rat Model of Hypoxic-Ischemic Brain Injury

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dc.contributor.authorAkisü M.
dc.contributor.authorKültürsay N.
dc.contributor.authorÇoker I.
dc.contributor.authorHüseyinov A.
dc.date.accessioned2019-10-27T00:31:58Z
dc.date.available2019-10-27T00:31:58Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractRecent data suggested that platelet-activating factor (PAF) could play a pathophysiologically important role in the progression of hypoxic-ischemic brain injury. We investigated brain tissue PAF concentration in the hypoxic-ischemic brain of immature rats. Endogenous PAF concentration in brain tissue showed a marked increase in hypoxic-ischemic pups (Group 1, 85.6 ± 15.5 pg/mg protein) when compared to that of the control (9.1 ± 3.1 pg/mg protein). In addition, we studied the effects of pretreatment with L-carnitine (5 days and 2 h before the hypoxia) on endogenous PAF concentration in the hypoxicischemic brain. Endogenous PAF concentration in the short-term pretreatment group (Group 2, 81.6 ± 9.7 pg/mg protein) was not different than in Group 1 rat pups. However, a significantly decreased PAF concentration was found in the group of pups that received carnitine pretreatment for 5 days (Group 3, 30.5 ± 11.0pg/mg protein). These results indicate that PAF is an important mediator in the immature rat model of cerebral hypoxic-ischemic injury. The suppressor effect of L-carnitine on PAF production may give new insight into the treatment of hypoxic-ischemic brain injury.en_US
dc.identifier.endpage187en_US
dc.identifier.issn0386-300X
dc.identifier.issue4en_US
dc.identifier.pmid9781268en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://hdl.handle.net/11454/23621
dc.identifier.volume52en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Medica Okayamaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCarnitineen_US
dc.subjectIschemiaen_US
dc.subjectPerinatal asphyxiaen_US
dc.subjectPlatelet-activating factoren_US
dc.subjectRaten_US
dc.titleThe Effect of L-Carnitine on Platelet Activating Factor Concentration in the Immature Rat Model of Hypoxic-Ischemic Brain Injuryen_US
dc.typeArticleen_US

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