Effects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammation

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dc.contributor.authorInce I.
dc.contributor.authorYesil-Celiktas O.
dc.contributor.authorKarabay-Yavasoglu N.U.
dc.contributor.authorElgin G.
dc.date.accessioned2019-10-27T08:35:12Z
dc.date.available2019-10-27T08:35:12Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study was conducted to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both samples were determined using HPLC. Then, carrageenan-induced paw edema was used to assess anti-inflammatory activity in mice. Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan. Intraperitoneal administration of both the extract and Pycnogenol® inhibited paw swelling dose-dependently at 2, 3, 4, 5 and 6 h after carrageenan injection. Both samples exhibited significant anti-inflammatory activities at doses of 75 and 100 mg/kg body wt. between 2 and 4 hours after administration (p<0.05), respectively. Additionally, P. brutia bark extract showed significantly better activity at doses of 75 and 100 mg/kg body wt. than indomethacine at the dose of 10 mg/kg body wt. (p<0.05). No acute toxicity was identified in intraplantar injection of the extract at a dose of 2000 mg/kg body wt.. Therefore, P. brutia bark extract possessing 3.3-fold more total catechins and 9.8-fold more taxifolin than Pycnogenol® can be utilized as an anti-inflammatory agent. © 2009 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorship06MUH007en_US
dc.description.sponsorshipThis project was supported by the Research Fund of Ege University (06MUH007). Special thanks to Horphag Research Ltd., UK for the donation of Pycnogenol ® . --en_US
dc.identifier.doi10.1016/j.phymed.2009.05.004en_US
dc.identifier.endpage1104en_US
dc.identifier.issn0944-7113
dc.identifier.issue12en_US
dc.identifier.pmid19577447en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1101en_US
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2009.05.004
dc.identifier.urihttps://hdl.handle.net/11454/27191
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPhytomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectPaw edema modelen_US
dc.subjectPine bark extracten_US
dc.subjectPinus brutiaen_US
dc.subjectPycnogenol®en_US
dc.subjectRaten_US
dc.titleEffects of Pinus brutia bark extract and Pycnogenol® in a rat model of carrageenan induced inflammationen_US
dc.typeArticleen_US

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