Clinical Characteristics of Patients with Bronchioloalveolar Carcinoma: A Retrospective Study of 44 Cases

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dc.contributor.authorDirican, Nigar
dc.contributor.authorBaysak, Aysegul
dc.contributor.authorCok, Gursel
dc.contributor.authorGoksel, Tuncay
dc.contributor.authorAysan, Tulin
dc.date.accessioned2019-10-27T21:42:27Z
dc.date.available2019-10-27T21:42:27Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Bronchioloalveolar carcinoma (BAC) is considered a subtype of adenocarcinoma of the lung. Recently BAC has been variously termed adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant invasive adenocarcinoma, and invasive mucinous adenocarcinoma. The aim of the study was to analyze and detect prognostic factors of patients with BAC over a 7-year period. Materials and Methods: This retrospective single-center study included 44 patients with BAC. The impact on survival of fifteen variables (gender, age, smoking status, cough, dyspnea, hemoptysis, fever, chest pain, sputum, metastasis number, Karnofsky performance status, pT, pN, TNM stage, cytotoxic chemoterapy) were assessed. Results: Median age was 55 years (38-83). Most patients were male (63.6%) and stage IV (59.1%). Twenty-one patients (47.7%) received cytotoxic chemotherapy (platinum-based regimens) for metastatic disease. Objective response rate was 33.3% (4 partial, 3 complete responses). Stable disease was observed in nine in patients (42.8%). Disease progression was noted in 5 (23.8%). The median OS for all patients was 12 months (95% CI, 2.08-22.9 months). Independent predictors for overall survival were: Karnofsky performance status (HR:3.30, p 0.009), pN (HR:3.81, p 0.018), TNM stage (HR:6.49, p 0.012) and hemoptysis (HR:2.31, p 0.046). Conclusions: Karnofsky performance status, pN, TNM stage and hemoptysis appear to have significant impact on predicting patient survival in cases of BAC.en_US
dc.identifier.doi10.7314/APJCP.2013.14.7.4365en_US
dc.identifier.endpage4368en_US
dc.identifier.issn1513-7368
dc.identifier.issue7en_US
dc.identifier.pmid23992004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4365en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.7.4365
dc.identifier.urihttps://hdl.handle.net/11454/46894
dc.identifier.volume14en_US
dc.identifier.wosWOS:000328269400062en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBronchioloalveolar carcinomaen_US
dc.subjecttreatmenten_US
dc.subjectsurvivalen_US
dc.subjectprognostic factorsen_US
dc.titleClinical Characteristics of Patients with Bronchioloalveolar Carcinoma: A Retrospective Study of 44 Casesen_US
dc.typeArticleen_US

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