Alginate/Chitosan NaaAlginate/Chitosan Nanoparticles for Adsorption and Controlled Release of Pemetrexed noparticles for Adsorption and Controlled Release of Pemetrexed

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dc.contributor.authorAk, Güliz
dc.contributor.authorErek, Ayça
dc.contributor.authorAktaş, Safiye Kübra
dc.contributor.authorÖzdemir, Yağmur
dc.date.accessioned2023-01-12T20:29:16Z
dc.date.available2023-01-12T20:29:16Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPemetrexed (PEM) is used for treatment of non-small cell lung cancer. However, PEM has disadvantages like fast elimination, low bioavailability, poor tumor cell selectivity, and penetration. Thus, there is a need for using pemetrexed delivery system to increase the anticancer effect of drug in lung cancer cells and to minimize its side effects. The purpose of this study is development of alginate/chitosan nanoparticles (ACNP) that have biodegradable and non-toxic structure for effective delivery of PEM for lung cancer therapy. In the present study, ACNP were prepared using the ionic gelation method, and pemetrexed was loaded via the adsorption method. Drug adsorption efficiency was calculated to be 57.80% and characterization studies were performed. In vitro drug release tests were carried out at pH levels of 5.5 and 7.4 with pemetrexed-loaded alginate/chitosan nanoparticles (PACNP) and free pemetrexed, and both the results were subsequently compared. Up to 11% release yield was observed at pH 5.5, and the yield reached up to 7% in pH 7.4 in the 25 hours. This nanoparticle system could be investigated in vitro and in vivo in further studies for controlled release of pemetrexed.en_US
dc.identifier.doi10.18185/erzifbed.1000206
dc.identifier.endpage1076en_US
dc.identifier.issn2149-4584
dc.identifier.issue3en_US
dc.identifier.startpage1066en_US
dc.identifier.trdizinid474523en_US
dc.identifier.urihttps://doi.org/10.18185/erzifbed.1000206
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/474523
dc.identifier.urihttps://hdl.handle.net/11454/80409
dc.identifier.volume14en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlginate/chitosan nanoparticleen_US
dc.subjectlung canceren_US
dc.subjectadsorptionen_US
dc.subjectpassive targetingen_US
dc.subjectpemetrexeden_US
dc.titleAlginate/Chitosan NaaAlginate/Chitosan Nanoparticles for Adsorption and Controlled Release of Pemetrexed noparticles for Adsorption and Controlled Release of Pemetrexeden_US
dc.typeArticleen_US

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