The antimicrobial and tissue healing efficacy of the atmospheric pressure cold plasma on grade III infected pressure ulcer: randomized controlled in vivo experiment

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dc.contributor.authorAkbiyik, A.
dc.contributor.authorSari, D.
dc.contributor.authorErcan, U. K.
dc.contributor.authorUyanikgil, Y.
dc.contributor.authorTasli, H.
dc.contributor.authorTomruk, C.
dc.contributor.authorUsta, Y. H.
dc.date.accessioned2021-05-03T20:33:16Z
dc.date.available2021-05-03T20:33:16Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractAim To evaluate the antimicrobial efficacy and wound healing effect of atmospheric pressure cold plasma (APCP) on an infected pressure ulcer (IPUs) model that was created on rats. Methods A total of 18 rats was divided into APCP, silver sulfadiazine (AgS) and control groups to have six rats in each group. A third-grade pressure ulcer model was developed on the back of each of the rats, and pressure ulcers were infected by inoculation of multidrug resistance (MDR) Pseudomonas aeruginosa. A portable dielectric barrier discharge device was used to generate cold air plasma. APCP, AgS and saline treatments were carried out once a day for 14 days. The effectiveness of the treatment was evaluated on days 5, 10 and 15. Surface area, depth, pressure ulcer healing scale (PUSH) and microbiological examination were used for evaluation. Results The results of this study showed that APCP was superior over AgS application and irrigation with saline by means of the reduction in surface area and depth of ulcers. Furthermore, PUSH score in plasma group was lower than other groups and histopathological examination showed a higher epithelization in APCP group. The average reductions of MDR P. aeruginosa for APCP, AgS and control groups were determined as 5.64 +/- 1.87, 1.91 +/- 0.90 and 1.22 +/- 0.88 log10 CFU per gram tissue, respectively. Conclusion Atmospheric pressure cold plasma healed IPUs better than AgS. Significance and Impact of the Study Portable cold plasma devices could be a potential novel treatment modality for the patients who have IPUs.en_US
dc.description.sponsorshipzmir Katip Celebi University [GAP-SABF-0001]en_US
dc.description.sponsorshipWe would like to thank zmir Katip Celebi University Scientific Research Projects Coordinator (2018-General Research Project; GAP-SABF-0001) for supporting the research budget. We would like to thank Yamac TEKINTAS for providing the bacterial strain.en_US
dc.identifier.doi10.1111/jam.14980en_US
dc.identifier.issn1364-5072
dc.identifier.issn1365-2672
dc.identifier.pmid33354899en_US
dc.identifier.scopus2-s2.0-85099103399en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/jam.14980
dc.identifier.urihttps://hdl.handle.net/11454/69933
dc.identifier.wosWOS:000606770000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatmospheric pressure cold plasmaen_US
dc.subjectinfected pressure ulcersen_US
dc.subjectmultidrug resistanceen_US
dc.subjectplasma medicineen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleThe antimicrobial and tissue healing efficacy of the atmospheric pressure cold plasma on grade III infected pressure ulcer: randomized controlled in vivo experimenten_US
dc.typeArticleen_US

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